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Biological tissue detection device based on space deviation Raman spectrum technology

A technology of Raman spectroscopy and biological tissue, which is applied in the field of medical testing, can solve problems such as not being able to be stored for a long time, and achieve the effects of easy control, high precision and high detection

Active Publication Date: 2018-09-04
中科凯利仪器设备(苏州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Similarly, its samples require special preparation and cannot be stored for a long time

Method used

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  • Biological tissue detection device based on space deviation Raman spectrum technology
  • Biological tissue detection device based on space deviation Raman spectrum technology
  • Biological tissue detection device based on space deviation Raman spectrum technology

Examples

Experimental program
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Embodiment 1

[0033] combine Figure 1-3 , this embodiment specifically describes the device of the present invention.

[0034] A portable biological tissue detection device based on space offset Raman spectroscopy technology, including a computer 1, a detection controller 2, an excitation light module 3, a laser 301, a spectroscopic module 4, a spectrometer 401, a three-degree-of-freedom mechanical arm 5, and SORS detection Head 6, detection platform 7, airtight sample chamber 8; excitation light module 3 includes laser 301, focusing lens 302, coupler 303, incident optical fiber 304, spectroscopic module 4 includes spectrometer 401, collecting optical fiber 402; It is characterized in that, the computer 1 is respectively connected with the detection controller 2, the laser 301, and the spectrometer 401. The laser 301 emits laser light and is coupled into the incident optical fiber 304 through the coupler 303 behind the focusing mirror 302. The incident optical fiber 304 is connected to the S...

Embodiment 2

[0048] The method of using the device of the present invention will be described in detail below. In this embodiment, a human tissue sample is detected.

[0049] Firstly, the sample to be tested is obtained, that is, the tissue sample taken from the lesion of the human body is subjected to preliminary pretreatment, and the pretreatment includes cleaning and stripping off non-detection substances.

[0050] Reshape the pretreated sample to make it comparable to the shape of the holding tank.

[0051] Prepare noble metal nanoparticle colloids, the preparation method of the noble metal nanoparticle colloids adopts the laser liquid phase ablation method, the diameter of the noble metal nanoparticles in the prepared noble metal nanoparticle colloids is about 50-200nm, and the noble metal nanoparticle colloids except noble metal nanoparticle The particles and water do not contain other impurities;

[0052] Mix the raw tissue with the noble metal nanoparticle colloid and then sonicat...

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Abstract

The invention belongs to the field of medical detection, and particularly relates to a portable biological tissue detection device based on a space deviation Raman spectrum technology. The biologicaltissue detection device comprises a computer, a detection controller, a laser, a spectrometer, a three-freedom-degree mechanical arm, an SORS detection head, a detection platform and a sealed sample chamber. An SORS technology is used; a sample to be tested is sealed; during the storage in dark places, equipment can be directly used for detecting the Raman spectrum, so that the detection is performed in a targeted way; the SORS technology and an SERS technology are used in a combined way; the defect of lower SORS detection biological sample signals is overcome; meanwhile, the problem that theSERS detection sample can only be used for detecting the expression information is solved; a novel SORS detection head is designed; the detection head has the advantages that the detection sensitivityis high; the control is easy; the displacement control precision is high; the influence by the precision of the step motor is avoided. The novel biological sample storage device is designed; the sample can be stored for a long time; the SORS signal detection can be detected at any time.

Description

technical field [0001] The invention belongs to the field of medical detection, and relates to a biological tissue detection device, in particular to a portable biological tissue detection device based on space offset Raman spectroscopy technology. Background technique [0002] In modern medical testing, biological tissue testing is an important way for medical diagnosis. Since changes in biological tissue will lead to changes in its internal tissue composition, by detecting biological tissue, obtaining information about its composition, and comparing it with healthy and diseased tissue composition information, the health status of the organism can be further determined. [0003] Raman spectroscopy is a useful tool for analyzing molecular structure. The characteristic peak position, intensity and line width of Raman spectrum can provide information on molecular vibration and rotation, reflecting different chemical bonds or functional groups. As a non-destructive, non-conta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 王复超付倩倩刘晓明张建帅
Owner 中科凯利仪器设备(苏州)有限公司
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