United gene marker for prostatic cancer treatment evaluation and detection kit thereof

A prostate cancer and combined labeling technology, applied in the determination/testing of microorganisms, biochemical equipment and methods, DNA/RNA fragments, etc., can solve the problems of no research and achieve the effect of good drug resistance

Inactive Publication Date: 2018-09-04
毛强平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There is no research on the use of miRNA to judge the drug resistance of docetaxel in HRPC

Method used

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  • United gene marker for prostatic cancer treatment evaluation and detection kit thereof
  • United gene marker for prostatic cancer treatment evaluation and detection kit thereof
  • United gene marker for prostatic cancer treatment evaluation and detection kit thereof

Examples

Experimental program
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Embodiment 1

[0033] We selected the following 3 sensitive genes that may be related to prostate cancer and 10 miRNA genes related to tumor pathogenesis, and analyzed their correlation with prostate cancer drug resistance. The genes are as follows:

[0034]

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Abstract

The invention provides a molecular marker combination for pre-evaluating drug resistance in a prostatic cancer chemotherapy process. The molecular marker is formed by two prostatic cancer sensitive genes (a P53 gene and a GSTP1 gene) and a miRNA (a miRNA-155), and can be applied for evaluating the chemotherapy drug resistance. In addition, the invention further provides a primer group and a kit for the evaluation; and the invention further provides application of the above primer group and kit in a united discriminant equation of molecular marker expression quantity. Through evaluating the relative expression quantity of the gene, the drug resistance existing in the combined prostatic cancer treatment of docetaxel and prednisone can be evaluated better.

Description

technical field [0001] The invention belongs to the technical field of prostate cancer treatment and diagnosis, and in particular relates to a gene combined marker used for evaluating the chemotherapy effect and drug resistance of prostate cancer, and a detection kit prepared from the combined marker. Background technique [0002] In recent years, the incidence of prostate cancer in my country has increased significantly. Different from the staging composition of prostate cancer patients in Western countries, nearly 70% of prostate cancer patients in my country are patients with advanced metastasis when they are first diagnosed. Although the vast majority of patients are sensitive to endocrine therapy, almost all patients will progress to hormone-resistant prostate cancer (HRPC) after 18 months of treatment, and the survival time of patients generally does not exceed 2 years. In 2004, the results of two studies, TAX327 and SWOC-9916, showed that compared with mitoxantrone...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/106C12Q2600/158C12Q2600/166
Inventor 不公告发明人
Owner 毛强平
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