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A 3d printed ink bag

A 3D printing and ink bag technology, applied in the biological field, can solve the problems of low efficiency, strict storage and transportation conditions, complicated processes, etc., and achieve the effect of avoiding unexpected mixing, simple preparation process and good uniformity.

Active Publication Date: 2021-03-26
THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process is complicated and the efficiency is low. Operational differences or pollution in any link of the operator will affect the quality of 3D printing ink and even 3D printing products, making it difficult to achieve the goal of standardization and mass production.
In addition, after the preparation of 3D printing bio-ink, due to the limitation of the properties of each component material, its stability is not easy to maintain, the storage and transportation conditions are strict, and the cost is high

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 3D printing bio-ink, including the following raw materials in mass percentage:

[0027] Extracellular Vesicle Suspension 10%

[0028] Pig dermal soft tissue derived extracellular matrix nanofiber powder 5%

[0029] Hydrochloric acid 1%

[0030] Ultrapure water balance.

[0031] A 3D printed ink bag, see figure 1 , comprising an inner bag 2 and an outer bag 1, the inner bag 2 is divided into three chambers by a partition 5, the porcine dermal soft tissue-derived extracellular matrix nanofiber micropowder is packed into the inner bag under low vacuum, and then vacuum-sealed to form a chamber 1; refill extracellular vesicle suspension, seal to form chamber 2, finally fill in water and hydrochloric acid mixed solution, seal to form chamber 3, the upper part of the inner bag is provided with an inlet 3, and the lower part is provided with an outlet 4, the inlet and The outlets are all sealed and extend out of the outer bag, and the outer bag vacuum-seals the inner bag. ...

Embodiment 2

[0035] The 3D printing bio-ink with a pH of 6.5 is made of the following raw materials in mass percentage:

[0036] Extracellular Vesicle Suspension 10%

[0037] Pig dermal soft tissue derived extracellular matrix nanofiber powder 5%

[0038] Hydrochloric acid 1%

[0039] Sodium bicarbonate amount

[0040] Ultrapure water balance.

[0041] A 3D printed ink bag, see figure 2 , including an inner bag 2 and an outer bag 1, the inner bag 2 is divided into four chambers by a partition 5, the upper part of the inner bag is provided with an inlet 3, and the lower part is provided with an outlet 4, the outlet is sealed, and the pig dermis soft tissue is loaded from the inlet under vacuum Derived extracellular matrix nanofiber micropowder is then heat-sealed to form chamber 1, then filled with extracellular vesicle suspension and heat-sealed to form chamber 2, then filled with water and hydrochloric acid and heat-sealed to form chamber 3, and finally filled to make the mixed biolo...

Embodiment 3

[0045] The 3D printing bio-ink with a pH of 6.9 is made of the following raw materials in mass percentage:

[0046] Extracellular Vesicle Suspension 30%

[0047] Pig dermal soft tissue derived extracellular matrix nanofiber powder 9%

[0048] Acetic acid 1%

[0049] Sodium bicarbonate amount

[0050] Ultrapure water balance.

[0051] A 3D printing ink bag, including an inner bag and an outer bag, the inner bag is divided into three chambers by a partition belt, filled with porcine dermis soft tissue-derived extracellular matrix nanofiber micropowder and acetic acid under low vacuum and then vacuum-sealed to form chamber 1, Then put water and sodium bicarbonate into it to vacuum-seal to form chamber 2, and finally put extracellular vesicle suspension into it to vacuum-seal to form chamber 3. The upper part of the inner bag is provided with an inlet, and the lower part is provided with an outlet, and the inlet and outlet are sealed and sealed. Stretch out the outer bag, whic...

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Abstract

The invention discloses a bag for 3D printing ink. The bag comprises an inner bag and an outer bag, wherein the outer bag is used for packaging the inner bag; the inner bag is divided into a pluralityof chambers by separating strips, and the plurality of chambers are respectively used for storing each component of the 3D printing ink; the upper part of the inner bag is provided with an inlet, thelower part of the inner bag is provided with an outlet, and the inlet and the outlet both penetrate the outer bag; and vacuum environments are formed in space in the inner and outer bags and space between the inner and outer bags. According to the invention, each component of the biological ink is separately stored in the plurality of chambers of the inner bag, which is beneficial for quantitative and stable preservation of each component of 3D printing ink; and in use of the 3D printing ink, the partition of the plurality of chambers of the inner bag can be removed through extrusion, and allthe components enter the totally-sealed inner bag without the partition for mixing, so preparation of the 3D printing ink is finished.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a 3D printing ink bag. Background technique [0002] At present, before using 3D printing inks, various biochemical raw materials are often manually weighed and proportioned, and the production of printing inks can be completed through steps such as mixing, stirring, heating, and centrifugation. The process is complicated and inefficient. Operational differences or contamination by operators in any link will affect the quality of 3D printing ink and even 3D printing products, making it difficult to achieve the goal of standardized and mass production. In addition, after the preparation of 3D printing bio-ink, its stability is not easy to maintain due to the limitation of the properties of each component material, the storage and transportation conditions are strict, and the cost is high. Contents of the invention [0003] In order to solve the above problems, the present invention...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M3/00C12M1/00B33Y30/00
CPCB33Y30/00C12M23/14C12M33/00
Inventor 陈蕾祁少海吴军傅炀廖冠睿侯映彤
Owner THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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