Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of Shengjiang Xiexin Decoction in the Treatment of Diarrhea Caused by Clostridium difficile Infection

A technology of ginger Xiexin decoction and Clostridium difficile, applied in the field of medicine, can solve the problems of decreased sensitivity to vancomycin and metronidazole, destruction of intestinal beneficial flora, high symptom recurrence rate, and recovery of intestinal bacteria. The effect of group balance, stable treatment effect and long onset time

Active Publication Date: 2022-02-18
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The following problems exist in the treatment of vancomycin and metronidazole: ① Destruction of beneficial intestinal flora; ② The sensitivity of some clinical isolates of Clostridium difficile to vancomycin and metronidazole decreases and the drug resistance rate increases; ③ Symptom recurrence rate as high as 15%-35% etc.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of Shengjiang Xiexin Decoction in the Treatment of Diarrhea Caused by Clostridium difficile Infection
  • Application of Shengjiang Xiexin Decoction in the Treatment of Diarrhea Caused by Clostridium difficile Infection
  • Application of Shengjiang Xiexin Decoction in the Treatment of Diarrhea Caused by Clostridium difficile Infection

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0050] 1. Materials

[0051] 1.1 Drugs

[0052] Dosage of vancomycin: 50mg / kg; medium dose of Jiangxiexin Decoction: 16.4g / kg, low dose of Jiangxiexin Decoction: 8.2g / kg, very low dose of Jiangxiexin Decoction: 4.1g / kg.

[0053] (Explanation: The dosage of Shengjiang Xiexin Decoction is based on the quality of the raw medicinal materials, and the low dosage group is equivalent to the equivalent dosage of the human dosage, and the administration method is intragastric administration).

[0054] 1.2 Animals

[0055] 4-5 weeks old C57BL / 6 mice, weighing 18±2g.

[0056] 2. Methods and results

[0057] The prescription of Shengjiang Xiexin Decoction is: Pinellia 9g, dried ginger 3g, coptis 3g, scutellaria baicalensis 9g, ginseng 9g, jujube 9g (broken), roasted licorice 9g, ginger 12g, the preparation method is to wash Pinellia with boiling water several times Afterwards, it is combined with other 7 herbs for decoction, and the medicinal solution is filtered and concentrated to a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicine, and in particular relates to the application of ginger Xiexin Decoction in treating diarrhea caused by Clostridium difficile infection. Based on the existing pharmacological activity of the ginger xiexin decoction, the present invention screens its new clinical efficacy through in-depth research through a large number of experiments. The experimental results show that the ginger xiexin decoction has the utility of treating diarrhea caused by clostridium difficile infection.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of ginger Xiexin Decoction in treating diarrhea caused by Clostridium difficile infection. Background technique [0002] Clostridium difficile (CD) is a Gram-positive anaerobic bacillus that is transmitted among humans through the fecal-oral route. With the widespread use or even abuse of broad-spectrum antimicrobials, the intestinal flora of patients is imbalanced, which is likely to induce Clostridium difficile infection (CDI), and then a series of diseases such as diarrhea and enteritis. Clostridium difficile infection has become a global epidemiological problem (Clincal InfectionDiseases.2007,45(3):302-307.). It is estimated that Clostridium difficile can be found in the stool of about 35% of hospitalized patients, the prevalence of Clostridium difficile infection in long-term hospitalized patients may be as high as 50%, and about 3% of healthy a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61K38/14A61P1/00A61P1/04A61P1/12A61P37/02
CPCA61K36/8888A61K36/9068A61K38/14A61P1/00A61P1/04A61P1/12A61P37/02A61K36/258A61K36/484A61K36/539A61K36/718A61K36/725
Inventor 黄璐琦苏建荣李慧杨洪军马致洁吕治林龙飞
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com