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Chlorpromazine tablet and preparation method thereof

A technology of chlorpromazine tablet and chlorpromazine hydrochloride, applied in the field of medicine, can solve the problems of low drug dissolution bioavailability, slow disintegration, burden and the like, and achieves convenient carrying and taking, high dissolution rate and low cost. Effect

Inactive Publication Date: 2018-08-28
HUAYI PHARMA ANHUI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology relates to an improved type of medications called dichloropromethane (chlormadinone). These drugs can help treat neurologically related conditions such as schizoid symptoms or other medical problems that may affect them over time. They work by blocking certain nerve cells from sending signals down their spinal cord through specific parts of our body. Different forms of this compound also include different chemical structures with similar properties but slightly modified versions.

Problems solved by technology

This patented problem addressed in this patents relates to improving the solubility and stability of drugs like dichlorproguanil (chemically called 1-(2-(dimethylamino)-2-methoxymorpholine), which can be used for treating certain medical conditions that cause nausea/vigorant effects. However current methods have limitations with regards to controlling its release rate over time without causing harmful side reactions.

Method used

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  • Chlorpromazine tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment example 1

[0028] A kind of chlorpromazine tablet, is made by the raw material of following weight ratio: 130 parts of lactose (314 types), 13 parts of cornstarch, 5 parts of povidone (K30), 18 parts of purified water, 28 parts of chlorpromazine hydrochloride 8 parts of carboxymethyl starch sodium (type A), 1 part of anhydrous silica gel, 1 part of magnesium stearate, 1 part of monkey mushroom extract, 5 parts of Opadry (21S58740), 44 parts of methanol, 65 parts of dichloromethane part, 0.3 part of antioxidant.

[0029] The antioxidant is stannous chloride.

[0030] The additive is one or more of talcum powder, cornstarch, and pharmaceutical grade cross-linked polyvinylpyrrolidone.

[0031] The water content of starch slurry is 10%-20%.

[0032] The preparation method of a kind of chlorpromazine sheet according to claim 1, is characterized in that: comprise the following steps:

[0033] (1), Lactose (type 314), cornstarch, and Hericium erinaceus extract are made into fillers using HZD...

Embodiment example 2

[0045] A kind of chlorpromazine sheet, is made by the raw material of following weight ratio: 135 parts of lactose (314 types), 15 parts of cornstarch, 6 parts of povidone (K30), 20 parts of purified water, 30 parts of chlorpromazine hydrochloride 10 parts of carboxymethyl starch sodium (type A), 2 parts of anhydrous silica gel, 2 parts of magnesium stearate, 2 parts of monkey mushroom extract, 6 parts of Opadry (21S58740), 45 parts of methanol, 66 parts of dichloromethane part, 0.4 part of antioxidant.

[0046] The antioxidant is stannous chloride.

[0047] The additive is one or more of talcum powder, cornstarch, and pharmaceutical grade cross-linked polyvinylpyrrolidone.

[0048] The water content of starch slurry is 10%-20%.

[0049] The preparation method of a kind of chlorpromazine sheet according to claim 1, is characterized in that: comprise the following steps:

[0050] (1), Lactose (type 314), cornstarch, and Hericium erinaceus extract are made into fillers using ...

Embodiment example 3

[0062] A kind of chlorpromazine tablet, is made by the raw material of following weight ratio: 140 parts of lactose (314 types), 7 parts of cornstarch, 7 parts of povidone (K30), 22 parts of purified water, 33 parts of chlorpromazine hydrochloride 12 parts of carboxymethyl starch sodium (type A), 3 parts of anhydrous silica gel, 4 parts of magnesium stearate, 3 parts of monkey mushroom extract, 7 parts of Opadry (21S58740), 46 parts of methanol, 68 parts of dichloromethane part, 0.5 part of antioxidant.

[0063] The antioxidant is stannous chloride.

[0064] The additive is one or more of talcum powder, cornstarch, and pharmaceutical grade cross-linked polyvinylpyrrolidone.

[0065] The water content of starch slurry is 10%-20%.

[0066] The preparation method of a kind of chlorpromazine sheet according to claim 1, is characterized in that: comprise the following steps:

[0067] (1), Lactose (type 314), cornstarch, and Hericium erinaceus extract are made into fillers using ...

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Abstract

The invention provides a chlorpromazine tablet, and relates to the technical field of medicines. The chlorpromazine tablet comprises lactose, corn starch, povidone K30, purified water, chlorpromazinehydrochloride, sodium carboxymethyl starch (class A), anhydrous silica gel, 1 to 4 parts of magnesium stearate, hedgehog mushroom extract, Opadry 21S58740, methanol, dichloromethane and an antioxidant, and the lactose (314 type), corn starch and hedgehog mushroom extract are prepared into a filler by using a mixer, chlorpromazine hydrochloride, the anhydrous silica gel, the sodium carboxymethyl starch (class A), and magnesium stearate are sieved by using a vibrating sieve or a stainless steel sieve, and then added to the mixer, and added with purified water to be prepared into a soft material,the povidone K30 and the antioxidant are added, and tabletting is performed by using a tabletting granulator, Opadry 21S58740, the methanol and dichloromethane are added to a coating machine to coata tablet, so that the chlorpromazine tablet is obtained. The chlorpromazine tablet disclosed by the invention has high utilization degree of the materials, stable disintegration and dissolution speed,high dissolution, stable quality, stable drug-release rate, convenient carrying and taking, and simple process, and reduces damage and burden of the tablet for stomach.

Description

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Claims

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Application Information

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Owner HUAYI PHARMA ANHUI CO LTD
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