Propranolol hydrochloride-polyvinyl alcohol porous hydrogel preparation as well as preparation method and application thereof

A technology of propranolol hydrochloride and porous hydrogel, which is applied in the field of medicine to avoid excessive hydration and eczema, has remarkable effect and improves air permeability

Inactive Publication Date: 2018-08-28
FUZHOU GENERAL HOSPITAL OF NANJING MILITARY COMMAND P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In theory, the higher the concentration of PVA, the greater the gel strength and the better the thermal stability. However, when the PVA concentration is greater than 20%, the viscosity of the solution is too high, and the formation of crosslinking points is affected when the molecular weight is large. more obvious

Method used

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  • Propranolol hydrochloride-polyvinyl alcohol porous hydrogel preparation as well as preparation method and application thereof
  • Propranolol hydrochloride-polyvinyl alcohol porous hydrogel preparation as well as preparation method and application thereof
  • Propranolol hydrochloride-polyvinyl alcohol porous hydrogel preparation as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Gel was prepared according to the following prescription (according to 1000g): propranolol hydrochloride 30g, chitosan 40g, PVA-124 120g, water-soluble azone 30g, propylene glycol 100g, glycerin 100g, anhydrous acetic acid 40g, absolute ethanol 200g , Purified water 340g.

Embodiment 2

[0064] Gel was prepared according to the following prescription (according to 1000g): propranolol hydrochloride 50g, chitosan 40g, PVA-124 120g, water-soluble azone 30g, propylene glycol 100g, glycerin 100g, anhydrous acetic acid 40g, absolute ethanol 200g , Purified water 320g.

Embodiment 3

[0066] Gel was prepared according to the following prescription (according to 1000g): propranolol hydrochloride 80g, chitosan 40g, PVA-124 120g, water-soluble azone 30g, propylene glycol 100g, glycerin 100g, anhydrous acetic acid 40g, absolute ethanol 200g , Purified water 290g.

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Abstract

The invention provides a propranolol hydrochloride-polyvinyl alcohol porous hydrogel preparation as well as a preparation method and application thereof. The propranolol hydrochloride-polyvinyl alcohol porous hydrogel is prepared from 1 to 10 percent of propranolol hydrochloride, 3 to 10 percent of gel matrix, and 3 to 20 percent of pore forming agent. The gel has good transdermal performance andair permeability, and after the gel is locally applied, a great amount of drug can remain on the skin to form a drug deposit. The propranolol hydrochloride-polyvinyl alcohol porous hydrogel preparation has a significant curative effect for treating angioma of babies, the adverse effect such as first-pass effect, sleep disorders, decreased heart rate and the like of the oral propranolol can be avoided, and the convenience and compliance in use can be improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a propranolol hydrochloride-polyvinyl alcohol porous hydrogel preparation and a preparation method and application thereof. Background technique [0002] Infantile hemangioma is a common benign tumor in early childhood, with an incidence rate of about 1.1-2.6%. It is characterized by the proliferation of vascular endothelial cells, and clinically manifests as red patches, papules, hypertrophic plaques, and masses of telangiectasia ( nodules). The natural course of the disease is self-regression after 1 year of age, but in a small number of patients, the hemangioma grows rapidly, festers and bleeds, or causes dysfunction, and even threatens life. [0003] In 2008, Leaute-Labreze et al reported for the first time in "New England Medicine" that propranolol hydrochloride could inhibit the proliferation of hemangiomas, which attracted the attention and imitation of pedia...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/32A61K47/36A61K47/38A61K47/10A61K31/138A61P35/00
CPCA61K9/0014A61K9/06A61K31/138A61K47/10A61K47/32A61K47/36A61K47/38A61P35/00
Inventor 宋洪涛张灵娜张敏新刘志宏陶春陈旭曾令军张佳良刘琳琳
Owner FUZHOU GENERAL HOSPITAL OF NANJING MILITARY COMMAND P L A
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