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Colorectal cancer DNA methylation marker, method for detecting colorectal cancer by using colorectal cancer DNA methylation marker and kit

A methylation marker and colorectal cancer technology, applied in the biological field, can solve problems such as poor compliance, psychological pain, and reduced willingness of the examinee to be screened, and achieve the effect of convenient detection and low cost

Inactive Publication Date: 2018-08-21
深圳市太科健康科技有限公司
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Problems solved by technology

The conventional gold standard for the diagnosis of colorectal cancer is colonoscopy, but it is traumatic and psychologically painful, and patients generally resist it; fecal occult blood test requires multiple sampling, which will bring a lot of inconvenience to patients, resulting in the screening of patients. Decreased willingness to investigate and poor compliance

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  • Colorectal cancer DNA methylation marker, method for detecting colorectal cancer by using colorectal cancer DNA methylation marker and kit
  • Colorectal cancer DNA methylation marker, method for detecting colorectal cancer by using colorectal cancer DNA methylation marker and kit
  • Colorectal cancer DNA methylation marker, method for detecting colorectal cancer by using colorectal cancer DNA methylation marker and kit

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[0047] The human ribosomal protein RPS24 gene includes 6 exons, which encode ribosomal protein S24, which is a component of ribosomal protein 40s. In vitro cell studies have shown that the abnormal expression of RPS24 gene is related to the proliferation and metastasis of colorectal cancer cells, but the specific mechanism is still unclear. The present inventors have found that colorectal cancer is related to the methylation of the sequence before and after the transcription start point of the first exon of the gene RPS24. The inventor speculates that the gene RPS24 may regulate gene expression through DNA methylation, which is one of the important factors leading to the occurrence of colorectal cancer.

[0048] In the publication, DNA methylation markers for predicting the occurrence of colorectal cancer are provided, said markers comprising methylation of at least one of the following genes: DZIP3 (cg14787155) and FXYD1 (cg17682828).

[0049] In one embodiment, the methylatio...

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Abstract

The invention discloses a colorectal cancer DNA methylation marker, a method for detecting the colorectal cancer by using the colorectal cancer DNA methylation marker, and a kit. The marker is methylation of gene FXYD1, DZIP3, RPS24, AKT2, UBTF, DAGLB, LPAR6, TP63, CX3CR1 and TACC2 sequences. The invention also discloses a probe, a method and a kit for detecting the DNA methylation marker, and a computer module for predicting the colorectal cancer occurrence risk by utilizing data of a DNA methylation site.

Description

technical field [0001] The invention belongs to the field of biotechnology. The present invention relates to disease detection; more specifically, the present invention relates to a DNA methylation marker of colorectal cancer and a method and kit for detecting colorectal cancer using it. Background technique [0002] The morbidity and mortality of colorectal cancer in my country rank fifth among all tumor morbidity and mortality respectively. For cancer, the significance of early screening far exceeds that of treatment. The conventional gold standard for the diagnosis of colorectal cancer is colonoscopy, but it is traumatic and psychologically painful, and patients generally resist it; fecal occult blood test requires multiple sampling, which will bring a lot of inconvenience to patients, resulting in the screening of patients. The willingness to check is reduced, and the compliance is poor. The hematological examination of cancer markers is non-invasive and convenient for...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/154
Inventor 李盛英陈颖罗浪宁争志龚伦军
Owner 深圳市太科健康科技有限公司
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