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Cosmetics comprising multi-layer nanoparticles encapsulating natural poorly soluble drugs as antiseptic substances and preparation method thereof

A technology of insoluble drugs and nanoparticles, applied in cosmetic preparations, cosmetics, pharmaceutical formulations, etc., can solve the problems of changing drug content, difficult size and drug content, and difficult to encapsulate natural insoluble drugs, etc., to improve long-term preservation. Effect

Active Publication Date: 2021-02-12
郑汉洙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, if polymer nanoparticles are applied to cosmetics for insoluble natural drugs, since the insoluble natural drugs are insoluble in water and have high viscosity, they will coagulate with each other over time even if they are emulsified and dispersed in water. If the size changes or the drug content decreases, it is difficult to maintain a certain size and drug content for a long time, so it is difficult to enclose natural insoluble drugs for cosmetics. Although people have continued to conduct many studies on this issue, they have not yet been satisfied. the results

Method used

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  • Cosmetics comprising multi-layer nanoparticles encapsulating natural poorly soluble drugs as antiseptic substances and preparation method thereof
  • Cosmetics comprising multi-layer nanoparticles encapsulating natural poorly soluble drugs as antiseptic substances and preparation method thereof
  • Cosmetics comprising multi-layer nanoparticles encapsulating natural poorly soluble drugs as antiseptic substances and preparation method thereof

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preparation example Construction

[0125] The present invention provides a method for preparing a cosmetic containing the multi-layered nano-particles encapsulating the above-mentioned natural insoluble drug as a preservative. A poloxamer compound represented by Chemical Formula 2, "a polyoxyether-based compound represented by the following Chemical Formula 3 or a polyoxygen castor oil-based compound represented by the following Chemical Formula 4", and a natural insoluble drug are mixed and subjected to heating or ultrasonic treatment ;and

[0126] Step 2, add natural polymer to the mixture of the above step 1 and stir.

[0127] [chemical formula 1]

[0128]

[0129] (In the above chemical formula 1,

[0130] R1 is hydrogen or methyl;

[0131] R2 is hydrogen or tetrahydrofuryl; and

[0132] n is an integer from 1 to 200);

[0133] [chemical formula 2]

[0134]

[0135] (In the above chemical formula 2,

[0136] l, m and p are integers from 1 to 200 respectively);

[0137] [chemical formula 3]

...

Embodiment 1

[0165] Preparation of Cosmetic 1 Containing Multilayered Nanoparticles Encapsulating Natural Insoluble Drugs as Antiseptic Substances

[0166] (1) Preparation of liquid cosmetics

[0167]Put frankincense (mastic, 100mg, mastic gum (HR-50850), importer: Hanbi Flavor Co., Ltd., place of origin: Greece), polyethylene glycol (PEG-400, 125mg), poloxamer 188 (500mg) and polyoxyethylene-20 cetyl ether (250mg) were mixed and the above mixture was heated to 50°C, and sodium alginate (2% aqueous solution, 1000mg) was added and stirred to form a multi-layered compound containing natural insoluble drugs. Nanoparticle liquid cosmetics.

[0168] (2) Preparation of solid cosmetics

[0169] The liquid cosmetic prepared in (1) above is dried under reduced pressure to prepare a solid cosmetic comprising multilayered nanoparticles encapsulating a naturally insoluble drug.

Embodiment 2

[0170] Preparation of Cosmetics 2 Containing Multilayered Nanoparticles Encapsulating Natural Insoluble Drugs as Antiseptic Substances

[0171] Except that polyethylene glycol (PEG-400, 250 mg) was used instead of polyethylene glycol (PEG-400, 125 mg) in the above Example 1, the rest were carried out in the same manner.

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Abstract

The present invention relates to cosmetics comprising a preservative, more specifically to cosmetics having an excellent long-term storage characteristic by comprising multi-layer nanoparticles as a preservative, the multi-layer nanoparticles, which has natural insoluble medicine encapsulated therein, stably maintaining medicine content while maintaining a set size of 0.001-40 nm not only immediately after production but even after long-term storage, and forming no precipitates when used as a preservative for liquid cosmetics.

Description

technical field [0001] The present invention relates to a cosmetic containing an antiseptic substance, and more specifically, the present invention relates to a cosmetic containing multilayered nanoparticles encapsulating a natural poorly soluble drug as an antiseptic substance so as to be excellent in long-term preservation. Background technique [0002] Among the natural substances that can be obtained from animals and plants, there are many natural medicines that can exert pharmaceutical activity in the human body. Examples thereof include mastic, powdered medicine, flavonoids, propolis, allicin, glucosamine, omegafatty acid, and the like. The above-mentioned frankincense inhibits or kills the growth of Helicobacter pylori and has a palliative effect on peptic ulcer. The above-mentioned powder has an anti-inflammatory and analgesic effect, and the above-mentioned flavonoid has an allergic reaction alleviating effect. Furthermore, the above-mentioned propolis has the eff...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/72A61K8/81A61K8/9789A61K8/98A61K8/36A61K8/02A61Q19/00
CPCA61K8/02A61K8/36A61K8/72A61K8/81A61K8/97A61K8/98A61Q19/00
Inventor 郑汉洙
Owner 郑汉洙
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