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Mercury ion fluorescence probe of benzimidazole [1, 2-a] pyridines derivative and application thereof

A technology of benzimidazole and fluorescent probe, which is applied in the fields of fluorescence/phosphorescence, luminescent materials, and material analysis through optical means, and can solve the problem of single fluorophore

Inactive Publication Date: 2018-08-14
TAISHAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although there are many detection methods for Hg 2+ Fluorescent probes have been reported, but the fluorophores of fluorescent probes are relatively single at present, so new fluorophores are developed to synthesize and detect Hg 2+ Fluorescent probes are of great significance

Method used

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  • Mercury ion fluorescence probe of benzimidazole [1, 2-a] pyridines derivative and application thereof
  • Mercury ion fluorescence probe of benzimidazole [1, 2-a] pyridines derivative and application thereof
  • Mercury ion fluorescence probe of benzimidazole [1, 2-a] pyridines derivative and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: The synthesis scheme of the compound of formula (1) is shown in the following formula:

[0016]

[0017] Concrete synthetic steps are as follows:

[0018] In a 50 mL round bottom flask, add 0.22 g (0.30 mmol) 2-phenylbenzimidazol[1,2-a]pyridine-3-carboxylhydrazide, 0.21 g (2.4 mmol) benzyl isothiocyanate Acyl, 20 mL acetonitrile, react at room temperature for 12 hours. Precipitation occurred during the reaction. Suction filtration and solid column chromatography gave 0.18 g of a yellow solid with a yield of 75%.

Embodiment 2

[0020] To the compound of formula (1) (5×10 -7 M) PBS / EtOH (8 / 2 v / v) buffer solution (pH=7.40) was added 2 equivalents of Mg 2+ , Ca 2+ , Al 3+ , S n 2+ , Pb 2+ , Cr 3+ , Mn 2+ , Fe 3+ , Co 2+ , Ni 2+ , Zn 2+ , Cd 2+ , Pd 2+ ,Hg 2+ and Ag + After measuring the change of its fluorescence emission intensity at 475nm, it was found that: the compound of formula (1) is 2+ Has better fluorescence selectivity, adding 2 equivalents of Hg 2+ After that, the fluorescence intensity of compound 1 increased significantly at 475nm, as shown in figure 1 , figure 2 shown.

Embodiment 3

[0022] Respectively in formula (1) compound (5 × 10 -7 M) and 2 equivalents of Mg 2+ , Ca 2+ , Al 3+ , S n 2+ , Pb 2+ , Cr 3+ , Mn 2+ , Fe 3+ , Co 2+ , Ni 2+ , Zn 2+ , Cd 2+ , Pd 2+ , Hg 2+ and Ag + In the solution of different metal ions, add 2 equivalents of Hg 2+ After measuring the change of its fluorescence emission intensity at 475nm, it was found that the compound of formula (1) has strong anti-interference ability to other ions, such as image 3 shown.

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Abstract

The invention discloses a benzimidazole [1, 2-a] pyridines hydrazine derivative Hg<2+> fluorescence probe, the probe is benzoyl isothiocyanate-substituted 2-phenylbenzimidazole [1, 2-a] pyridine-3-formylhydrazine, and the chemical structural formula is shown in the formula (1). The fluorescence probe has better fluorescence selectivity, higher sensitivity and stronger ability to resist other ion interference for Hg<2+> in a PBS / EtOH(8 / 2 v / v) buffered solution (a pH value equals to 7.40), and has a wide application prospect.

Description

technical field [0001] The invention relates to the field of organic small molecule fluorescent probes, in particular to a Hg 2+ Synthesis and application of fluorescent probe benzimidazol[1,2-a]pyridine derivatives. Background technique [0002] Mercury is a heavy metal that is widely used. Fluorescent lamps, computers, mobile phones, batteries and other electronic products in daily use all use mercury-containing materials to varying degrees. After these electronic products are used up and discarded, some mercury finally enters the environment in the form of ions, causing serious pollution to the environment. Mercury ions have a great impact on animals, plants and human health. For example, mercury ions are highly toxic to the human brain, kidneys, intestines and stomach and nervous system. Therefore, the identification and detection of mercury ions has important applications in the fields of environmental science, life science and medicine. Many methods have been report...

Claims

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Application Information

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IPC IPC(8): C09K11/06C07D471/04G01N21/64
CPCC09K11/06C07D471/04C09K2211/1007C09K2211/1029C09K2211/1044G01N21/643
Inventor 葛燕青吉瑞雪刘爱坤徐志扬
Owner TAISHAN MEDICAL UNIV
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