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A method for screening illegal additives in health food

A health food and illegal additive technology, which is applied in the direction of instruments, measuring devices, scientific instruments, etc., can solve the problems that hinder the health food safety monitoring and early warning system, and cannot screen illegal additives, so as to achieve rapid and convenient screening and identification Effect

Active Publication Date: 2021-02-19
HUNAN ACADEMY OF INSPECTION & QUARANTINE +1
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Problems solved by technology

Therefore, it is impossible to conduct a comprehensive and rapid screening of illegal additives in health food, which hinders the establishment of health food safety monitoring and early warning system

Method used

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  • A method for screening illegal additives in health food
  • A method for screening illegal additives in health food

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Embodiment 1

[0011] 1. Establish a high-resolution mass spectrometry screening library for the names, corresponding molecular formulas, second-order fragment ions, third-order fragment ions, and Nth-order fragment ions of weight loss compounds, and the precise molecular weight of the retention time.

[0012] 2. Take a sample of a weight loss capsule on the market, pour out the contents and smash the capsule shell together, and mix to obtain the sample.

[0013] 3. Use acetonitrile as solvent, ultrasonic extraction, and C18 powder purification for sample pretreatment.

[0014] Weigh 1.000g of sample into a 25mL centrifuge tube, add 15mL of acetonitrile, ultrasonically extract for 20min, let cool to room temperature, transfer all the samples to a 25mL volumetric flask, wash the centrifuge tube with 10mL of acetonitrile several times, and combine the cleaning solution into the volumetric flask , and make up to the mark with acetonitrile, shake well, and let stand for 5 min. Take 2 mL of supe...

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Abstract

The invention relates to a method for screening illegal additives in health food, and uses high-performance liquid chromatography ion trap time-of-flight tandem mass spectrometry to screen and confirm illegal additives in health food. Through spectral library search, molecular formula prediction, and multi-level fragment ion mass spectrum identification, known and non-target compounds can be detected, and their fragmentation rules can be inferred based on fragment ion information. The method is simple and fast, is a "non-target" detection analysis, has a wide screening range, and can obtain accurate and reliable conclusions without using standard or reference substances. It is suitable for rapid screening and identification of weight-loss illegal additives and other illegal additives in food and medicine.

Description

technical field [0001] The invention relates to a method for screening illegal additives in health food, belonging to the technical field of food and drug detection. Background technique [0002] At present, there have been many research reports on the detection of illegally added chemical substances in health products at home and abroad, mainly focusing on the qualitative and quantitative analysis of known compounds. Analysis methods include ultraviolet spectrophotometry, thin layer chromatography, high performance liquid chromatography, high performance liquid chromatography-tandem mass spectrometry and so on. The main hidden dangers of illegal drug addition in health food are unclear dosage, unclear compatibility relationship, unknown drug source, and unclear drug impurities. This brings difficulties to the selection of screening targets, and it is necessary to establish a sensitive and specific analytical method to identify and detect illegally incorporated chemicals in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/884
Inventor 张帆黄志强王美玲张莹颜鸿飞
Owner HUNAN ACADEMY OF INSPECTION & QUARANTINE
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