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Application of flos carthami parasite in preparing drug or healthcare product preventing and treating gout

A technology of safflower parasitism and health care products, applied in the directions of application, drug combination, function of food ingredients, etc., can solve problems such as unreported pharmacological effects of safflower parasitism on gout and the like

Inactive Publication Date: 2018-08-10
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, so far, the pharmacological effects of safflower parasites on the treatment of gout have not been reported

Method used

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  • Application of flos carthami parasite in preparing drug or healthcare product preventing and treating gout
  • Application of flos carthami parasite in preparing drug or healthcare product preventing and treating gout
  • Application of flos carthami parasite in preparing drug or healthcare product preventing and treating gout

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Intervention effect of safflower parasite on sodium urate-induced acute gouty arthritis rats

[0022] 1 Animals, materials, reagents and instruments

[0023] 1.1 Experimental animals

[0024] SPF grade healthy male SD rats, weighing 180 ± 20g, were purchased from the Experimental Animal Center of Kunming Medical University (certificate number: SCXK (Dian) k2015-0002); experimental rat feed was purchased from the Experimental Animal Center of Kunming Medical University, (qualified Certificate number: SCXK (Dian) k2015-0003). The experiment was approved by the Ethics Committee of the Animal Experiment Center of Yunnan University of Traditional Chinese Medicine (No.: R-0620170010). Before the experiment, all rats were fed adaptively for 1 week. During the adaptive feeding period, the animals had free access to food and water. The breeding room was kept quiet, the indoor temperature was maintained at 23-25° C., the humidity was 55-75%, and the fluorescent lamp...

Embodiment 2

[0061] Example 2: Protective effect of safflower parasite on human umbilical vein endothelial cells induced by sodium urate

[0062] 1 Materials, reagents and instruments

[0063] 1.1 Reagents and materials

[0064] Human umbilical vein endothelial cell line (HUVEC; Shanghai Bogu Biotechnology Co., Ltd.); allopurinol (AlfaAesar, USA); sodium urate (Sigma, USA); Tris (Sigma, USA); high glucose medium (DMEM; USA Hyclone company); Fetal bovine serum (U.S. Thermo company); Trizol Reagent (U.S. Invitrogen company); M-mLV reverse transcriptase (U.S. Promega company); Xanthine oxidase (XOD) test box, ICAM-1 test box and IL-1β test kit was purchased from Nanjing Jiancheng Bioengineering Institute; penicillin, streptomycin, trypsin, dimethyl sulfoxide (DMSO), 3-(4,5-dimethylthiazole-2)-2,5 -Diphenyltetrazolium bromide (MTT) and phosphate buffered saline (PBS) were purchased from Beijing Dingguo Changsheng Biotechnology Co., Ltd.; experimental water was Milli-Q ultrapure water; other ...

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Abstract

The invention provides application of flos carthami parasite in preparing a drug or a healthcare product preventing and treating gout. By inspecting the influence of flos carthami parasite extract onthe ankle joint swelling degree, the activity of serum uric acid and xanthine oxidase and the contents of serum IL-1 beta, IL-8 and TNF-a of a rat with acute gouty arthritis of a sodium urate induction injury, and by inspecting the influence of the flos carthami parasite extract on the human umbilical veins endothelial cell activity, the contents of cell supernatant, ICAM-1 and IL-1 beta, the activity of XOD and the expression amount of XOD mRNA in the cells of the sodium urate induction injury, it is found that the flos carthami parasite extract has the pharmacologic action of relieving goutfor the first time.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine and health care products, in particular to a medicine and health care product application of safflower parasitism. Background technique [0002] Gout is an inflammatory joint disease caused by the deposition of monosodium urate in or around the joints, and is directly related to hyperuricemia caused by purine metabolism disorders, decreased uric acid excretion, or increased uric acid in the body. Therefore, clinically, hyperuricemia is the main feature, and about 5% to 12% of patients with hyperuricemia will develop gout. The main clinical features of acute gout are acute arthritis and chronic tophi disease, mainly including acute onset arthritis, tophi chronic arthritis, urate nephropathy and uric acid urolithiasis. Traditional Chinese medicine classifies gout into categories such as "arthritis syndrome", "turbidity of urine", and "severe joint", manifested as internal dampness and he...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P19/06A23L33/105
CPCA23L33/105A23V2002/00A61K36/185A61K2236/331A61K2236/333A61K2236/39A61P19/06A23V2200/30A23V2250/21
Inventor 杨兴鑫俞捷彭小骥顾雯董金材
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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