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Anti-tumor medicine composition and application thereof

A composition and anti-tumor technology, applied in the field of pharmaceutical compositions of anti-tumor drugs, can solve the problems of not too low reduction level and high dosage of isothiocyanate

Inactive Publication Date: 2018-07-13
HI MAG HEALTH TECH CO LTD SHENZHEN
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a pharmaceutical composition of an antitumor drug and its use, aiming at solving the problem of using isothiocyanate alone as an antitumor component in the prior art, because the reduction level of ROS is relatively not too low, therefore, Problems with higher doses of isothiocyanates

Method used

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  • Anti-tumor medicine composition and application thereof
  • Anti-tumor medicine composition and application thereof
  • Anti-tumor medicine composition and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0042] Inhibitory effect of a pharmaceutical composition of PEITC and ferric ammonium citrate (FAC) on osteosarcoma cells

[0043] Cell lines and cell culture: The cells used in the experiment include osteosarcoma cells MG-63, MNNG / HOS and U2OS. The culture conditions of all cells are: in a carbon dioxide incubator at 37°C, saturated humidity, and a carbon dioxide content of 5%, grow in DMEM medium containing 10% fetal bovine serum and 1% double antibody, MG-63 and MNNG / HOS was passaged every two days, U2OS was passaged every four days, and the medium was changed once in between.

[0044] Cells in the logarithmic phase were collected and prepared into 5×10 4 cells / mL of single-cell suspension. The cell suspension was inoculated into 96-well culture plates at 100 uL per well, and after culturing in a carbon dioxide incubator for 24 hours, the original culture medium was discarded. Add culture medium containing different concentrations of PEITC (0.25uM, 1uM and 10uM) and 100...

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Abstract

The invention provides an anti-tumor medicine composition. The medicine composition comprises at least one isothiocyanate derivative and at least one iron preparation. The anti-tumor medicine composition provided by the invention contains at least one isothiocyanate derivative and at least one iron preparation. On the premise of improving the oxidation level by combining the isothiocyanate derivative with GSH, after the iron preparation enters into the body, the content of Fe<2+> inside tumor cells can be obviously increased through the siderophilic characteristic of tumor cells, the Fe<2+> ions participate in a Fenton reaction to further produce ROS, and then a GSH anti-oxidation system inside the cells is inhibited, a stable oxidoreduction state is broken, and ROS inside the cells is maintained to a relatively high level. The ROS can perform a lipid peroxidation reaction with lipids to produce lipid ROS, and the ROS damages lipids and proteins and also cause DNA damage, so that the death of the cells is promoted.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compositions, and in particular relates to a pharmaceutical composition of antitumor drugs and its application. Background technique [0002] Isothiocyanates (ITCs) are a class of small molecular substances with N=C=S structure, which are abundant in cruciferous vegetables, such as radish, cabbage, broccoli, cauliflower, and kale. There are many kinds of isothiocyanates, and the isothiocyanates with anti-tumor effect that are often exposed to in the diet mainly include: allyl isothiocyanate (AITC), phenyl isothiocyanate (BITC), Phenylethyl isothiocyanate (PEITC) and sulforaphane (SFN). [0003] Isothiocyanate is a rapid inducer that inhibits the growth of cancer cells. In animal experiments, isothiocyanate selectively inhibits the occurrence of animal tissue tumors. Its mechanism of action is the same as that of isothiocyanate effectively inhibiting cytochrome 4P50 enzymes Metabolizing carcinogens,...

Claims

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Application Information

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IPC IPC(8): A61K33/26A61K31/26A61P35/00
CPCA61K33/26A61K31/26A61K2300/00
Inventor 商澎吕欢欢甄晨晓尹大川贾斌
Owner HI MAG HEALTH TECH CO LTD SHENZHEN
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