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Anti-tumor medicine composition and application thereof

A composition and anti-tumor technology, applied in the field of pharmaceutical compositions of anti-tumor drugs, can solve the problems of inability to use anti-tumor drugs and low anti-tumor activity, and achieve the effect of inhibiting metastasis and growth

Inactive Publication Date: 2018-07-13
HI MAG HEALTH TECH CO LTD SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to provide a pharmaceutical composition of an antineoplastic drug and its use, aiming to solve the problem that sulfasalazine alone has low antitumor activity and cannot be used as an antitumor drug in the prior art

Method used

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  • Anti-tumor medicine composition and application thereof
  • Anti-tumor medicine composition and application thereof
  • Anti-tumor medicine composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Inhibitory effect of a SASP and ferrous ammonium sulfate (FAS) pharmaceutical composition on osteosarcoma cells

[0039] Cell lines and cell culture: The cells used in the experiment include osteosarcoma cells MG-63, MNNG / HOS and U2OS. The culture conditions of all cells are: in a carbon dioxide incubator at 37°C, saturated humidity, and a carbon dioxide content of 5%, grow in DMEM medium containing 10% fetal bovine serum and 1% double antibody, MG-63 and MNNG / HOS was passaged every two days, U2OS was passaged every four days, and the medium was changed once in between.

[0040] Cells in the logarithmic phase were collected and prepared into 5×10 4 cells / mL of single-cell suspension. The cell suspension was inoculated into 96-well culture plates at 100 uL per well, and after culturing in a carbon dioxide incubator for 24 hours, the original culture medium was discarded. Add culture medium containing different concentrations of PEITC (0.25uM, 1uM and 4uM) and 10uM FA...

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Abstract

The invention provides an anti-tumor medicine composition, and the medicine composition comprises salicylazosulfapyridine (SASP) and at least one iron preparation. The anti-tumor medicine compositionprovided by the invention contains at least one SASP and at least one iron preparation. The quantity of GSH is reduced indirectly by indirectly inhibiting cystine / cysteine transporter in SASP, the iron preparation can participate in a Fenton reaction on the premise of reducing the reduction level, the oxidation level is improved to further generate ROS, and then a GSH anti-oxidation system insidecells is inhibited, a stable oxidoreduction state is broken, and ROS inside the cells is maintained to a relatively high level. The ROS can perform a lipid peroxidation reaction with lipids to producelipid ROS, and the ROS damages lipids and proteins and also cause DNA damage, so that the death of the cells is promoted.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compositions, and in particular relates to a pharmaceutical composition of antitumor drugs and its application. Background technique [0002] In general, cysteine ​​is necessary for protein synthesis and plays an important role in maintaining glutathione (GSH) levels. Glutathione is a tripeptide thiol composed of glutamic acid, cysteine ​​and glycine. GSH has a short half-life and its biosynthetic rate is limited by the cysteine ​​content. Decreased cellular uptake of extracellular cystine / cysteine ​​leads to decreased intracellular GSH levels and subsequent growth arrest. Cells acquire cystine / cysteine ​​mainly through two pathways. On the one hand, cells can directly take up extracellular cystine through the cystine / glutamate transporter, or nearby activated macrophages, dendritic cells, fibroblasts, etc. After taking up cystine, it is reduced to cysteine ​​and secreted into the microenvironmen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/26A61K31/655A61P35/00
CPCA61K31/655A61K33/26A61K2300/00
Inventor 商澎吕欢欢甄晨晓尹大川贾斌
Owner HI MAG HEALTH TECH CO LTD SHENZHEN
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