A plasma adsorption and filtration device for the production of coagulation factor blood products

Abstract

The invention discloses a plasma adsorption filtration device for producing blood coagulation factor blood products. The plasma adsorption filtration device comprises a plasma adsorption tank, a plasma conveying system and a gel filter, wherein a speed-adjustable stirring device, a plasma inlet and a gel adding hole are arranged at the top end of the plasma adsorption tank; a temperature control interlayer is arranged on the tank, and a plasma outlet is formed in the bottom end of the tank; the plasma conveying system consists of a liquid material conveying pipe and a liquid material conveyingpump; a speed-adjustable stirring scraper is arranged at the top end of the gel filter; an inner filter screen is arranged inside the gel filter; a gel outlet is formed in the bottom end of the gel filter; a feed port and a discharge port are formed in the upper end and the lower end of the side surface of the gel filter respectively; the gel filter is provided with an automatic solid stripping system with a differential pressure controller. The plasma adsorption filtration device achieves streamlined treatment of automatic gel filtration and collection in the production process of the bloodcoagulation factor blood products, so that the labor intensity of working staff is greatly reduced; meanwhile, the pressure difference is stable and controllable in the whole filtration process, so that the blood coagulation factor components and gel particles are better protected.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals and blood products, and in particular relates to a plasma adsorption filtration device used in the gel adsorption process used in the production process of coagulation factor blood products. Background technique [0002] my country's blood product industry is in a state of serious shortage of supply and demand, and the imbalance between supply and demand has led to a high degree of prosperity in the blood product industry. The raw materials for the production of blood products are all the same batch of plasma, so if more products can be extracted from the same batch of plasma, the core competitiveness of the enterprise can be effectively improved; Separate as many protein species as possible from a batch of plasma. [0003] At present, the low-temperature ethanol method is still the most widely used separation method in the production of blood products, but with the advancement of tech...

AI Technical Summary

Problems solved by technology

The current gel filtration collection mainly uses manual filtration, the filtration efficiency is low, time-consuming and labor-intensive, and there is a risk of plasma contamination; at the same time, because some types of gel particles are relatively fragile, the concentration of solids gradually increases as the filtration proceeds , the filter pressure difference increases, and the excessively high pressure difference will destroy the fragile gel particles, which increases the material loss in the production process, and the broken colloid particles flow into the plasma tank, which will also cause disadvantages to the subsequent production process influences

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