Application and expression of NR4A2 gene in pituitary adenoma biomarker

Abstract

The invention discloses an application and an expression of an NR4A2 gene in a pituitary adenoma biomarker, in particular to the technical field of applications of natural ribonucleotide. An NR4A2 gene belongs to an orphan nuclear receptor subfamily in a nuclear receptor family and is used for identifying an object probably suffering from pituitary adenoma or invasiveness of pituitary adenoma. Theexpression of NR4A2 from a pituitary adenoma tissue sample of the object is detected, wherein NR4A2 with higher expression shows that the invasiveness of the pituitary adenoma of the object is high and is related with increase of the possibility of bad prognosis of the object. The invention provides the application of the NR4A2 gene. The expressions of the NR4A2 gene in tissue of invasive pituitary adenoma and non-invasive pituitary adenoma patients are different, and therefore, the NR4A2 gene has the application prospects of becoming the pituitary adenoma biomarker.

Description

technical field [0001] The present invention relates to the application of NR4A2 gene in biomarkers of pituitary adenoma, specifically the technical field of application of natural ribonucleotides. Background technique [0002] Pituitary adenoma (pituitary tumor for short) is one of the most common intracranial tumors in humans, accounting for about 10%-15% of intracranial tumors. Pituitary tumors are benign tumors histologically, but some pituitary tumors grow aggressively, enveloping or invading the surrounding tissue structure, and it is difficult to completely remove this part of the tumor, which is one of the main reasons for tumor recurrence. According to the biological behavior of pituitary tumors, they can be divided into non-invasive pituitary tumors, invasive pituitary tumors and pituitary carcinomas. Invasive pituitary tumors are between non-invasive pituitary tumors and pituitary carcinomas. Their histological appearance is benign, but their biological character...

AI Technical Summary

Problems solved by technology

Invasive growth makes it difficult to completely remove the tumor by surgery, and the commonly used drugs bromocriptine and somatostatin have poor curative effects on this type of tumor; invasive growth also limits its sensitivity to radiotherapy, and radiotherapy in the sellar region is easy Damage to important structures such as the normal pituitary gland, hypothalamus, and optic nerve

These factors lead to high postoperative recurrence rate and rapid growth of tumor residual tissue in aggressive pituitary adenomas

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