Sustained-release pharmaceutical composition containing venlafaxine hydrochloride as well as preparation method thereof

Abstract

The invention belongs to the field of a pharmaceutical composition for treating depression, more exactly relates to a new pharmaceutical composition of a venlafaxine hydrochloride sustained release tablet as well as a preparation method thereof. The pharmaceutical composition of the sustained release tablet consists of the following components according to weight proportion: each tablet contains 75 mg of venlafaxine hydrochloride, 25 to 250 mg of glyceryl behenate, 15 to 200 mg of hydroxypropyl methylcellulose, 20 to 200 mg of anhydrous calcium hydrogen phosphate, 1.8 to 7.2 mg of silicon dioxide and 1.8 to 7.2 mg of magnesium stearate; and the venlafaxine hydrochloride sustained release tablet is prepared by a melting granulation method, the sustained release tablet prepared by the methodcan continuously and stably release the medicine within 24 hours, stable blood concentration is maintained, the medicine use times of patients are reduced, and the medicine use safety and the compliance of the patients are improved. Compared with other granulation methods, the preparation method is time-saving and energy-saving, so the preparation process is simple, rapid and economic, solvent residues are avoided and the preparation method is suitable for industrialized production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compositions for treating depression, and in particular relates to a novel pharmaceutical composition of venlafaxine hydrochloride sustained-release tablets and a preparation method thereof. Background technique [0002] Venlafaxine is a phenylethylamine derivative and a reuptake inhibitor of 5-HT, norepinephrine and dopamine, among which the reuptake inhibitory effect on 5-hydroxytryptamine is the strongest, and the reuptake inhibitory effect on norepinephrine is also strong. Stronger, weaker inhibitory effect on dopamine reuptake. [0003] The antidepressant effect appears faster than other antidepressants, the side effects are smaller than imipramine, and the effect is better than imipramine, and its curative effect is equivalent to that of trazodone. Higher doses of venlafaxine (greater than 150 mg per day) are more effective than low doses. It is clinically used to treat depression, anxiety, o...

AI Technical Summary

Problems solved by technology

Wet granulation requires the addition of binders and the drying of the obtained granules, which requires a certain amount of manpower, material resources and time

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