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Method for degrading chloramphenicol antibiotics in soil or clay

A technology for chloramphenicol and antibiotics, which is applied in the field of degrading chloramphenicol antibiotics in soil or clay, can solve the problems of complicated operation, low degradation rate, high energy consumption, etc., and achieves simple operation, low degradation cost and high removal rate. Effect

Active Publication Date: 2018-06-22
SHANGHAI ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a degradable soil or clay in order to overcome the problems of large energy consumption, complex operation, low degradation rate or serious pollution in the prior art when treating chloramphenicol antibiotics in soil. The method of chloramphenicol antibiotics

Method used

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  • Method for degrading chloramphenicol antibiotics in soil or clay
  • Method for degrading chloramphenicol antibiotics in soil or clay
  • Method for degrading chloramphenicol antibiotics in soil or clay

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Test product: take 2 g of the sieved clay sample, add chloramphenicol (3.3*10 -6 mol, thiamphenicol (3.3*10 -6 mol), fluthiamphenicol (3.3*10 -6 mol). Vortex with a vortex mixer for 0.5 to 1 minute; add 2 mL of potassium persulfate aqueous solution with a concentration of 0.1 mol / L, add 2 mL of a ferrous sulfate solution with a concentration of 0.1 mol / L, and vortex with a vortex mixer for 0.5 to 1 minute. Stand still for 4 hours, and detect the chloramphenicol antibiotics in the clay after the reaction according to the sample processing method described in 1.1 and the instrument analysis conditions in 1.2.

[0060] Reference substance: take 2 g of the sieved clay sample, add chloramphenicol (3.3*10 -6 mol), thiamphenicol (3.3*10 -6 mol), fluthiamphenicol (3.3*10 -6 mol); vortex with a vortex mixer for 0.5 to 1 minute; detect the chloramphenicol antibiotics in the reference substance according to the sample processing method described in 1.1 and the instrument anal...

Embodiment 2

[0071] Other operations and methods are the same as in Example 1, the only difference is that the volume of the ferrous sulfate solution added to the test product is 1 mL.

[0072] Experimental results:

[0073]

[0074]

[0075] After testing, the degradation rates of chloramphenicol, thiamphenicol and fluthiamphenicol in the clay sample were 75.3%, 74.4% and 73.8%, respectively. And after degradation, no by-products of benzoic acid are generated, and the measured benzoic acid contains a substance with a benzoic acid structure.

Embodiment 3

[0077] Other operations and methods are the same as in Example 1, the only difference is that the volume of the potassium persulfate aqueous solution added is 4 mL.

[0078] Experimental results:

[0079] Types of antibiotics

[0080] After testing, the degradation rates of chloramphenicol, thiamphenicol and fluthiamphenicol in the clay sample were 97.9%, 97.8% and 97.8%, respectively. And after degradation, no by-products of benzoic acid are generated, and the measured benzoic acid contains a substance with a benzoic acid structure.

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Abstract

The invention discloses a method for degrading chloramphenicol antibiotics in soil or clay. According to the method, ferrous ions or peroxysulphate is used for degrading chloramphenicol compounds in the soil or clay. The method is simple in operation, low in cost, free of pollution and high in speed, pollution to by-products is avoided, and the removal rate on the chloramphenicol antibiotics in the soil is high.

Description

technical field [0001] The invention relates to a method for degrading chloramphenicol antibiotics in soil or clay. Background technique [0002] Chloramphenicol antibiotics are a class of dichloroacetamide derivatives with 1-phenyl-2-amino-1-propanol, also known as amide alcohols, such antibiotics include chloramphenicol (Chloramphenicol) and its derivatives Thiamphenicol (Thiamphenicol), florfenicol (Florfenicol), etc. As a cheap broad-spectrum antibiotic, chloramphenicol is widely used in the treatment of various infectious diseases in humans and animals. Studies have found that chloramphenicol has serious toxic reactions to the human hematopoietic system and digestive system. Long-term micro-intake of chloramphenicol can induce drug resistance of pathogenic bacteria, lead to an imbalance of normal flora in the body, and make people susceptible to various diseases . In view of the above reasons, many countries and regions have begun to ban or strictly restrict the use ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B09C1/08G01N30/02G01N30/06
CPCB09C1/08G01N30/02G01N30/06
Inventor 周佳欣周昌艳宋卫国白冰姚春霞
Owner SHANGHAI ACAD OF AGRI SCI
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