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Preparation method of Erchen drug extract with antitumor-resisting activity and preparation thereof

A technology of anti-tumor activity and extract, which is applied in the field of preparation of Erchen extract and its preparations, can solve the problems of inconvenient portability, poor taste, large volume and dosage, etc. easy-to-use effects

Active Publication Date: 2018-06-15
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Existing traditional Chinese medicine decoctions have large volume and dosage, poor taste, and are not easy to carry. There is no Erchen extract and its preparations with antitumor activity mainly composed of Erchen polysaccharides.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Mix 30 kg of pinellia, 30 kg of tangerine peel, 18 kg of poria cocos and 9 kg of licorice, add them to the frying pan, add water to decoct at a material-to-liquid ratio of 1:8 (W / V), and cook at a temperature of 85°C for 1 hour each time. Cook for a total of 2 times. Filter the decoction and concentrate under reduced pressure to a concentrated solution with a specific gravity of 1.15. Slowly add ethanol to the concentrated solution and stir rapidly. The final concentration of ethanol is 60%. After standing for 4 hours, pour off the supernatant and centrifuge to obtain a precipitate. Dissolve the precipitate with distilled water, filter, discard the insoluble matter, obtain the aqueous solution after the precipitate is dissolved in distilled water, adjust the specific gravity of the aqueous solution to 1.10, and then place the aqueous solution in a dialysis bag with a molecular weight cut-off of 8000 for routine dialysis for 12 hours. The inner liquid (aqueous solution) ...

Embodiment 2

[0032]Mix 15 kg pinellia, 15 kg tangerine peel, 9 kg poria cocos and 4.5 kg licorice, add them to the frying pan, add water to decoct at a material-to-liquid ratio of 1:10 (W / V), and cook at a temperature of 88°C for 0.5 hours each time , decocted 3 times in total. Filter the decoction and concentrate under reduced pressure to a concentrated solution with a specific gravity of 1.20. Slowly add ethanol to the concentrated solution and stir rapidly. The final concentration of ethanol is 70%. After standing for 3 hours, pour off the supernatant and centrifuge to obtain a precipitate. Dissolve the precipitate with distilled water, filter, discard the insoluble matter, obtain the aqueous solution after the precipitate is dissolved in distilled water, adjust the specific gravity of the aqueous solution to 1.12, and then place the aqueous solution in a dialysis bag with a molecular weight cut-off of 7000 for routine dialysis for 18 hours, and dialyze The inner liquid (aqueous solutio...

Embodiment 3

[0034] Mix 7.5 kg pinellia, 7.5 kg tangerine peel, 4.5 kg poria cocos and 2.25 kg licorice, add them to the frying pan, add water to decoct at a material-to-liquid ratio of 1:12 (W / V), and cook at a temperature of 90°C for 1 hour each time , A total of 2 decoctions. Filter the decoction and concentrate under reduced pressure to a concentrated solution with a specific gravity of 1.30. Slowly add ethanol to the concentrated solution and stir rapidly. The final concentration of ethanol is 80%. After standing for 2 hours, pour off the supernatant and centrifuge to obtain a precipitate. Dissolve the precipitate with distilled water, filter, discard the insoluble matter, obtain the aqueous solution after the precipitate is dissolved in distilled water, adjust the specific gravity of the aqueous solution to 1.15, and then place the aqueous solution in a dialysis bag with a molecular weight cut-off of 6000 for routine dialysis for 24 hours, and dialyze The inner liquid (aqueous soluti...

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PUM

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Abstract

The invention relates to a preparation method of an Erchen drug extract with antitumor-resisting activity and a preparation thereof, and belongs to the technical field of Chinese pharmaceutical manufacturing. The preparation method of the Erchen drug extract comprises the following steps: matching Erchen drug decoction prepared from rhizoma pinelliae, pericarpium citri reticulatae, poria and liquorice root according to ancient herbal formula dosage, adding water for decocting, filtering and carrying out vacuum concentration on the decoction; adding ethanol into the concentrated solution subjected to decoction, dissolving ethanol precipitation and dialyzing; carrying out vacuum concentration on the intra-dialysate and then carrying out vacuum drying to obtain the Erchen drug extract with the antitumor-resisting activity. According to the Erchen drug extract with the antitumor-resisting activity, disclosed by the invention, the extractive yield is high, the polysaccharide content of theextract is higher than 75 percent and the antitumor activity of the Erchen drug extract is better than that of Erchen drug decoction. An excipient is added into the Erchen drug extract to obtain the Erchen drug extract preparation with the antitumor activity; compared with traditional Erchen drug decoction, the preparation prepared by adding the excipient into the Erchen drug extract has the advantages of good anti-tumor effects, convenience in administration, improvement on the compliance of patients and capability of being widely used. The preparation method disclosed by the invention has the advantages of simple and feasible process and suitability for industrialized mass production.

Description

technical field [0001] The invention relates to a preparation method of Erchen extract with antitumor activity and its preparation, which belongs to the technical field of traditional Chinese medicine pharmacy. Background technique [0002] Erchen Decoction originated from the "Daping Huimin Heji Bureau Prescription" in the Song Dynasty. It is composed of four traditional Chinese medicines: pinellia, tangerine peel, poria cocos and licorice. In the prescription, pinellia is the king, which is good at drying dampness and phlegm, and can reduce adverse events and harmonize the stomach, dissipate stagnation and eliminate swelling; tangerine peel is the minister, regulates qi and stagnation, dries dampness and eliminates phlegm, makes qi smooth and phlegm disappears; adjuvant with Poria cocos, expelling dampness and invigorating the spleen , with the source of Du Shengphlegm; with licorice as an adjuvant medicine, to reconcile the properties of the medicine and to invigorate the...

Claims

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Application Information

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IPC IPC(8): A61K36/8888A61K9/48A61P35/00
CPCA61K9/48A61K36/076A61K36/484A61K36/752A61K36/8888A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 陈华圣孙建许爱华夏子豪凌子成袁田宇
Owner YANGZHOU UNIV
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