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Composition comprising ginseng derived exosome like vesicles for skin whitening

A technology of exosomes and compositions, which is applied in the field of preparation of the ginseng-derived exosome-like vesicles, can solve the problem of no report on the skin whitening effect of exosome-like membrane structure vesicles

Active Publication Date: 2018-06-08
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For ginseng, although skin lightening effects of ginseng-derived extracts or their components have been reported, skin lightening effects of ginseng-derived exosome-like membrane-structured vesicles have not been reported

Method used

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  • Composition comprising ginseng derived exosome like vesicles for skin whitening
  • Composition comprising ginseng derived exosome like vesicles for skin whitening
  • Composition comprising ginseng derived exosome like vesicles for skin whitening

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Example 1. Isolation of ginseng-derived exosome-like vesicles

[0093] (Step 1) First, juice containing ginseng root extracellular fluid is prepared by pressing 4-year-old ginseng root

[0094] (Step 2) Centrifuge the juice at 4° C. and 500 times of acceleration of gravity for 10 minutes to obtain a supernatant. Then, the supernatant was further centrifuged at 4°C and 3,000 times the acceleration of gravity for 20 minutes and the supernatant was collected.

[0095] (Step 3) Add 0.5mL of 2.5M sucrose, 1mL of 0.8M sucrose and 32mL of impurity-free supernatant to a 35mL ultracentrifuge tube sequentially, and ultracentrifuge the tube at 4°C and 100,000 gravitational acceleration multiples for 2 hours. After ultracentrifugation, ginseng root exosome-like vesicles were located between the 2.5M sucrose layer and the 0.8M sucrose layer due to their density. Therefore, the layer containing ginseng root exosome-like vesicles was isolated by removing the solution from the upper ...

Embodiment 1

[0118] [Preparation Example 1] soft capsule

[0119] Mix 50mg of ginseng-derived exosome-like vesicles, 80-140mg of L-carnitine, 180mg of soybean oil, 2mg of palm oil, 8mg of hydrogenated vegetable oil, 4mg of yellow beeswax, and 6mg of lecithin, and dispense each capsule according to a commonly used method Fill to 400mg.

Embodiment 2

[0120] [Formulation Example 2] Tablet

[0121] Mix 50 mg of ginseng-derived exosome-like vesicles, 200 mg of galactooligosaccharides, 60 mg of lactose, and 140 mg of maltose, granulate the mixture using a fluidized bed dryer, add 6 mg of sugar esters, and then compress into tablets using a tablet machine to prepare tablet.

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PUM

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Abstract

Disclosed in the present disclosure are a composition for skin whitening containing ginseng-derived exosome-like vesicles and a method for preparing the ginseng-derived exosome-like vesicle. The ginseng-derived exosome-like vesicle may have a diameter of 20-500 nm and may be isolated from ginseng root. The composition containing the ginseng-derived exosome-like vesicles as an active ingredient hasan effect of preventing, improving or treating a skin pigmentation disease such as melasma, freckle, lentigo, nevus, melanoma, etc. by effectively suppressing melanin production.

Description

technical field [0001] The invention discloses a composition containing ginseng-derived exosome-like vesicles for skin whitening and a method for preparing the ginseng-derived exosome-like vesicles. Background technique [0002] Most animal cells have the ability to secrete cell-derived extracellular vesicles of various sizes and compositions. These extracellular vesicles are present in all biological fluids, including blood, urine, saliva, and media for cell culture (Loyer X, Vion AC, Tedgui A, Boulanger CM. Microvesicles as cell-cell messengers incardiovascular diseases. Circ Res 2014; 114:345-53; Ohno S, Ishikawa A, Kuroda M. Roles of exosomes and microvesicles in disease pathogenesis. Adv Drug Deliv Rev 2013; 65:398-401). [0003] Extracellular vesicles are membrane-structured vesicles with a diameter of approximately 20 nm to 5 μm. They vary in size and composition and contain various species such as exosomes (approximately 30-100 nm), ectosomes, micelles (approximate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61Q19/02
CPCA61Q19/02A61K36/258A61K2800/413A61K8/9789A61K8/14A61P17/00A61P43/00
Inventor 崔瑞娟崔银廷宾范浩黄景焕曹恩敬李泰龙
Owner AMOREPACIFIC CORP
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