Pharmaceutical composition for preventing or treating onychomycosis and preparation method therefor

A technology for onychomycosis and a composition, applied in the field of pharmaceutical compositions for preventing or treating onychomycosis and the field of preparation thereof, can solve problems such as limited therapeutic activity, difficulty in softening keratin, and the like, and achieve increased effect and increased moisture retention. ability, the effect of preventing drying phenomenon

Active Publication Date: 2018-06-05
WOOSHIN LABOTTACH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the topical preparations for treating onychomycosis known in the prior art that do not contain antifungal drugs are preparations in the form of lacquer, and it is difficult to achieve a satisfactory effect of softening cuticles, thereby exhibiting sufficient therapeutic activity. is limited

Method used

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  • Pharmaceutical composition for preventing or treating onychomycosis and preparation method therefor
  • Pharmaceutical composition for preventing or treating onychomycosis and preparation method therefor
  • Pharmaceutical composition for preventing or treating onychomycosis and preparation method therefor

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preparation example Construction

[0023] The invention also provides a method for preparing the pharmaceutical composition. That is, the present invention provides a method for preparing a pharmaceutical composition for the prevention or treatment of onychomycosis that has the ability to soften keratin and maintain moisture, which includes mixing urea, fumaric acid, 1,3-butanediol, and gel forming polymerization A hydrogel is formed by a compound, a crosslinking agent, 45-60% by weight of water, and one or more additives selected from plasticizers, tackifiers, surfactants, chelating agents and preservatives.

[0024] The urea, fumaric acid, 1,3-butanediol, gel forming polymer, crosslinking agent, plasticizer, tackifier, surfactant, chelating agent and preservative are as described above.

[0025] The mixing can be carried out by mixing and stirring all the ingredients at a time under appropriate heating. In addition, it can also be implemented by the following method: first prepare a plurality of mixed liquids con...

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Abstract

The present invention provides: a hydrogel type pharmaceutical composition for preventing or treating onychomycosis, containing urea, fumaric acid, 1,3-buthylene glycol, a gel-forming polymer, a cross-linking agent, and 45 to 60 wt% of water, and having keratolytic and moisture-retention abilities; and a preparation method therefor.

Description

Technical field [0001] The present invention relates to a pharmaceutical composition for preventing or treating onychomycosis and a preparation method thereof. In more detail, the present invention relates to a pharmaceutical composition having keratolysis and moisture-retention ability for prevention or treatment The pharmaceutical composition for onychomycosis is in the form of a hydrogel containing urea, fumaric acid and 1,3-butanediol as active ingredients. Background technique [0002] Onychomycosis is a fungal infection of fingernails and / or toe nails, which mainly occurs due to infections such as Trichophytonrubrum and Trichophyton mentagrophytes. At present, systemic treatment and local treatment are performed for onychomycosis. Although antifungal agents such as terbinafine and itraconazole are used for the systemic treatment of onychomycosis, they can cause side effects including gastrointestinal side effects, headache, liver toxicity, and the like. Lacquer formulatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/32A61K31/047A61K31/17A61K31/194A61P31/10
CPCA61K31/047A61K31/17A61K31/194A61K47/32A61K2300/00A61K31/045A61K9/0014A61K9/06A61K9/7023A61P31/10
Inventor 南泽秀
Owner WOOSHIN LABOTTACH CO LTD
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