Injection prepared from taxodiaceae plant volatile oil and application thereof

A plant volatile oil and injection technology, applied in the field of medicine, can solve the problems of no reports on the anticancer activity of metasequoia cones and no research on bald cypress, achieve good liver cancer cell proliferation, inhibit liver cancer cell proliferation, and simple preparation method Effect

Active Publication Date: 2018-06-01
XINYANG AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the research on metasequoia in the field of medicine, since the metasequoia was discovered in my country in the 1940s, domestic and foreign research on metasequoia has been continuously carried out. Flavonoids, terpenes, and lignins have been isolated from metasequoia seeds. , carotene, sterols and other chemical components, modern pharmacological studies have shown that the chemical components in metasequoia seeds have anti-cardiovascular and cerebrovascular effects, antibacterial and antioxidant effects, but no reports have been found on the anti-cancer activity of metasequoia cones. There is no research on the application of bald cypress and pool fir in the field of medicine

Method used

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  • Injection prepared from taxodiaceae plant volatile oil and application thereof
  • Injection prepared from taxodiaceae plant volatile oil and application thereof
  • Injection prepared from taxodiaceae plant volatile oil and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] An injection prepared from the volatile oil of the Firaceae plant, each component is calculated by weight percentage, as follows: the volatile oil of Metasequoia fruit is 5%, 15-hydroxystearic acid polyethylene glycol is 6%, and medicinal ethanol is 3%, Citric acid is 6%, water for injection is 80%.

Embodiment 2

[0028] An injection prepared from the volatile oil of Firaceae plant, each component is calculated by weight percentage, as follows: 2% of the volatile oil of the clover cones, 8% of polyethylene glycol 15-hydroxystearate, and 10% of medicinal ethanol %, citric acid is 1%, and water for injection is 79%.

Embodiment 3

[0030] An injection prepared from the volatile oil of Cedaraceae plant, each component is calculated by weight percentage, as follows: 8% of the volatile oil of the cypress fruit, 10% of polyethylene glycol 15-hydroxystearate, and 20% of medicinal ethanol , vitamin E is 3%, and water for injection is 59%.

[0031] The following test examples demonstrate the in vitro cytotoxic activity and strength of the volatile oil of the firaceae plant on human liver cancer cell HepG2.

[0032] CCK-8 method was used to test the in vitro cytotoxic activity and strength of the volatile oil extracted from the cones of Pondus chinensis, the volatile oil extracted from the cones of Taxus chinensis and the volatile oil extracted from the cones of Metasequoia on human liver cancer cells HepG2.

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PUM

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Abstract

The invention provides an injection prepared from taxodiaceae plant volatile oil and application thereof. The injection is prepared from, in percentage by weight, 2-8% of taxodiaceae plant volatile oil, 6-10% of a solubilizer, 3-20% of a cosolvent, 0.1-6% of a stabilizer and water for injection which is supplied to be 100%, wherein taxodiaceae plant volatile oil is volatile oil extracted from cones of pond cypress, swamp cypress or metasequoia. According to the injection prepared from taxodiaceae plant volatile oil provided by the invention, volatile oil is extracted from cones of taxodiaceaeplants, so that the activity of proliferation of human hepatocarcinoma cells can be better inhibited; the injection is safe and innoxious, and the preparation method is simple and suitable for industrial production. The injection prepared from taxodiaceae plant volatile oil can be used for preparing anti-tumor injections, is high-efficient and innoxious, and can be available for clinical use.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an injection prepared from the volatile oil of a firaceae plant and an application thereof. Background technique [0002] Primary liver cancer (PLC, hereinafter referred to as liver cancer) is a common malignant tumor. Due to the insidious onset, no symptoms or no obvious symptoms in the early stage, and rapid progression, most patients have reached locally advanced stage or developed distant metastasis when diagnosed. , difficult to treat, and seriously threaten the health and life safety of the people. Currently recognized treatment options are surgery combined with radiotherapy, chemotherapy and immunotherapy. Although these measures have achieved a certain effect on the treatment of liver cancer, they are prone to oral ulcers, diarrhea, and peripheral leukocytosis caused by bone marrow suppression and other toxic and side effects. At the same time, there are poor anti-tumor...

Claims

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Application Information

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IPC IPC(8): A61K36/13A61K9/08A61P35/00
CPCA61K9/0019A61K9/08A61K36/13A61K47/14A61K2236/37
Inventor 杨俊杰陈琼王海燕陈重潘岩刘琰郭心灵李玄
Owner XINYANG AGRI & FORESTRY UNIV
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