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Method for preparing small-size cellulose nanocrystal

A cellulose and nanocrystal technology, which is applied in the field of preparation of small-sized cellulose nanocrystals, can solve the problems that the particle size of cellulose nanocrystals is not seen, the cellulose nanocrystals cannot meet the particle size requirements of cellulose nanocrystals, and the like, Achieve the effect of high yield, easy operation and easy availability of raw materials

Inactive Publication Date: 2018-05-29
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In patent CN105777913A, alkali solution is used to pretreat plant cellulose raw materials, and then acid hydrolysis is used to prepare cellulose nanocrystals with a particle size of 150-350nm. The cellulose nanocrystals obtained by this method cannot meet the requirements of cellulose nanocrystals. Particle size requirements when used as a drug carrier
There are still many cases of preparing cellulose nanocrystals by acid hydrolysis, but no case of cellulose nanocrystals with a particle size of less than 50nm has been seen.

Method used

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  • Method for preparing small-size cellulose nanocrystal

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Cut 4.6g of cotton into rods with a length and diameter of about 5-7nm and 1.5-2nm, add it to 200mL of sulfuric acid solution with a concentration of 64%, and react for 40min at a temperature of 45°C. dilution. Take the upper suspension and centrifuge at 10,000rpm for 20min at 10°C to obtain a white solid. Ultrasonically disperse the white solid in 40mL of water, and centrifuge under the above conditions (repeat the operation 3 times). Finally, the white solid is dispersed in 40mL of water. Dialysis treatment (molecular weight cut-off Da: MW: 3500), the sample after dialysis treatment was freeze-dried to obtain larger size cellulose nanocrystals. Weigh 0.25g of larger sized cellulose nanocrystals and dissolve in 10mL of DMSO, add 0.5g of sodium tert-butoxide and dissolve in 10mL of DMSO solution at a temperature of 45°C, react for 72h, and the obtained product is dispersed in 150mL at a temperature of 10°C The dispersion was centrifuged at 10000 rpm for 20 min at 10°C,...

Embodiment 2

[0023] The type of raw materials used, the amount and the process flow are the same as those in Example 1, except that the DMSO solution containing 0.25 g of larger-sized cellulose nanocrystals is added, and 0.5 g of potassium tert-butoxide is dissolved in 10 mL of DMSO, with a yield of 79% %. The measured average size of the obtained cellulose nanocrystals is less than 50nm.

Embodiment 3

[0025] The type of raw materials used, the amount and the process flow are the same as those in Example 1, except that the DMSO solution containing 0.3 g of larger-sized cellulose nanocrystals is added, and 0.6 g of lithium tert-butoxide is dissolved in 10 mL of DMSO, with a yield of 81 %. The measured average size of the obtained cellulose nanocrystals is less than 50nm.

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Abstract

The invention provides a method for preparing a small-size cellulose nanocrystal. The method is characterized by comprising the following steps: performing acidification hydrolysis on a cellulose rawmaterial so as to obtain a cellulose nanocrystal of relatively large molecules, and further treating the cellulose nanocrystal with a tert-butyl alcohol salt, thereby obtaining a cellulose nanocrystalof which the particle size is smaller than 50nm. The method provided by the invention is gentle in reaction condition, easy to control, simple and easy in reaction raw material obtaining, and is an efficient method for preparing small-size cellulose nanocrystals.

Description

technical field [0001] The invention relates to a preparation method of small-sized cellulose nanocrystals. Background technique [0002] Cellulose nanocrystals are widely used in wastewater treatment, energy and electronics fields due to their superior properties and easy surface modification. In recent years, cellulose nanocrystals have been continuously reported to be used in the biomedical field. For example, by modifying the surface groups of cellulose nanocrystals, tissue engineering scaffolds, gene carriers, antibacterial and anti-tumor materials based on cellulose nanocrystals have been developed. Drug carriers and catalysts, etc. Cellulose nanocrystals have low cytotoxicity and have been proven to be a promising carrier for cancer therapy (Czaja WK, Young DJ, Kawecki M, Brown RM. The future prospects of microbial cellulose inbiomedical applications[J]. Biomacromolecules, 2007 ; 8(1):1-12). [0003] Cellulose nanocrystals come from different sources and have diffe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B15/02
CPCC08B15/02
Inventor 于冰丛海林谷传涛苗亚伟申有青
Owner QINGDAO UNIV
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