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Application of traditional Chinese medicine composition in preparation of medicine for preventing and treating diabetic retinopathy

A technology of diabetic retinopathy and composition, applied in the field of application of traditional Chinese medicine composition in the preparation of drugs for preventing and treating diabetic retinopathy

Active Publication Date: 2020-05-19
GUANGZHOU BAIYUNSHAN ZHONGYI PHARMA COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is a shortage of medicines that can invigorate the liver and kidney to treat the root cause, and can clear the liver, improve eyesight and eliminate pathogenic factors to treat the symptoms. The curative effect of preventing and treating diabetic retinopathy, delaying the process of retinopathy, or preventing the occurrence of related complications

Method used

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  • Application of traditional Chinese medicine composition in preparation of medicine for preventing and treating diabetic retinopathy
  • Application of traditional Chinese medicine composition in preparation of medicine for preventing and treating diabetic retinopathy
  • Application of traditional Chinese medicine composition in preparation of medicine for preventing and treating diabetic retinopathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Effects of Zhangyanming Tablets on Diabetic Retinopathy in db / db Spontaneously Diabetic Mice

[0017] 1. Purpose of the experiment

[0018] This experiment uses the db / db spontaneous diabetic mouse model commonly used in the world at present, uses the 4Doct small animal fundus imaging system to detect the changes in the number of retinal microvascular tumors in the fundus, observes the effect of Zhangyan Ming tablets on the retinopathy of db / db mice, and explores the use of Prevention and treatment of diabetic retinopathy with drugs prepared from Zhangyanming Tablets.

[0019] 2. Test materials and methods

[0020] 2.1 Experimental animals and grouping

[0021] SPF grade spontaneous diabetic mouse model C57BL / KsJ-db / db mouse (abbreviated as db / db mouse), 6-8 weeks old, weighing 45-55g, female, provided by Shanghai Experimental Animal Center of Chinese Academy of Sciences / Shanghai Slack Provided by Laboratory Animals LLC. The feeding and environment of the animals fo...

Embodiment 2

[0057] Clinical Observation of Curative Effect of Zangyanming Tablets on Diabetic Retinopathy

[0058] 1. Purpose of the test

[0059] This experiment clarified the clinical curative effect of Zangyanming tablets in treating diabetic retinopathy by comparing the curative effects of taking Zangyanming tablets in treating diabetic retinopathy and taking calcium dobesilate in treating diabetic retinopathy.

[0060] 2. Materials and methods

[0061] 1. General Information

[0062] All observed cases were 144 cases in 3 research hospitals in different regions of the country. Before treatment, the gender, age, diabetic retinopathy stage, and TCM symptom scores of the two groups were compared, P>0.05, the difference was not statistically significant, indicating that the two groups were comparable.

[0063] 2. Case selection criteria

[0064] 2.1 Case inclusion criteria

[0065] (1) Those who meet the diagnosis of type 2 diabetes and diabetic retinopathy.

[0066] (2) Diabetic re...

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Abstract

The invention discloses application of a traditional Chinese medicine composition in preparation of a medicine for treatment of diabetic retinopathy. The traditional Chinese medicine composition comprises the following components: rhizoma acori graminei, semen cassiae, cistanche, root of kudzu vine, feather cockscomb seed, radix codonopsis, fructus viticis, Chinese wolfberry, semen plantaginis, radix paeoniae alba, dogwood, licorice, dodder seed, rhizoma cimicifugae, hedge prinsepia nut, chrysanthemum, butterflybush flower, Rhizoma Chuanxiong, polygonati rhizoma processed with yellow wine, prepared rehmannia root, Phellodendron amurense and Radix Astragali. The traditional Chinese medicine composition has good effects on preventing and treating the diabetic retinopathy, and can significantly reduce the production of retinal microangioma of the diabetic retinopathy, and compared with commonly-used diabetic retinopathy therapeutic drug calcium dobesilate, the traditional Chinese medicinecomposition is more remarkable in curative effect.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to the application of a traditional Chinese medicine composition in the preparation of drugs for preventing and treating diabetic retinopathy. Background technique [0002] Diabetic retinopathy (DR) is one of the most serious complications of diabetic systemic complications, and it is also one of the most important clinical manifestations of diabetic microangiopathy. In the early stage, there is generally no sensation and no effect on vision. Ischemia and hypoxia lead to new blood vessels, which affect vision and cause severe blindness, which is the main cause of blindness in adults in developed countries, and its threat to vision has been increasingly valued by our country. With the increasing number of people with diabetes and the prolongation of life expectancy, the prevalence of DR is also increasing, and it has become the most common cause of blindness in middle-a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61P3/10A61P9/10A61P27/02
CPCA61K36/21A61K36/236A61K36/287A61K36/344A61K36/39A61K36/40A61K36/43A61K36/481A61K36/482A61K36/484A61K36/488A61K36/56A61K36/64A61K36/65A61K36/68A61K36/71A61K36/73A61K36/756A61K36/804A61K36/815A61K36/85A61K36/888A61K36/8969A61K2300/00
Inventor 尹震吴燕梅耿春贤刘珊珊梁海清张春波邹琦
Owner GUANGZHOU BAIYUNSHAN ZHONGYI PHARMA COMPANY
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