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Application of undaria pinnatifida extract in preparation of alpha-glucosidase inhibitor

A technology of wakame extract and glucosidase, which is applied in the direction of drug combination, plant raw materials, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2018-05-29
QUANZHOU NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report on the inhibitory effect of wakame extract on α-glucosidase activity.

Method used

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  • Application of undaria pinnatifida extract in preparation of alpha-glucosidase inhibitor
  • Application of undaria pinnatifida extract in preparation of alpha-glucosidase inhibitor
  • Application of undaria pinnatifida extract in preparation of alpha-glucosidase inhibitor

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Experimental program
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Embodiment

[0022] 1. Instruments and reagents

[0023] Microplate reader (TECAN F50).

[0024] AB-8 macroporous adsorption resin (Shanxi Bohui Biochemical Technology Co., Ltd.), acarbose (Bayer Pharmaceutical and Healthcare Co., Ltd., National Drug Approval H19990205, No. 6924147651014), α-glucosidase, 4-nitrobenzene-α -D-Glucopyranosides were purchased from Sigma.

[0025] Fresh wakame is produced in Weihai, Shandong, China.

[0026] 2. Preparation of Wakame Extract

[0027] 2.1 Preparation of supernatant part of wakame water extraction and ethanol precipitation

[0028] Take the fresh wakame that has been removed, wash and drain, cut it into pieces, freeze-dry it in vacuum at -80°C, and grind it into a wakame powder with a particle size of about 0.15 μm; : water = 3g: 100mL ratio mixing, 40 ℃, 40KHz ultrasonic (power 600W) assisted extraction for 30min, take the filtrate and carry out rotary evaporation and concentration under the conditions of 55 ℃ and -0.1MPa with a rotary evapor...

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Abstract

The invention discloses an application of an undaria pinnatifida extract in preparation of an alpha-glucosidase inhibitor. Research indicates that the undaria pinnatifida extract has a certain inhibition effect on activity of alpha-glucosidase, the enzyme inhibition type is mixed type-I inhibition, and the development of the undaria pinnatifida extract as the alpha-glucosidase inhibitor is feasible.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to the application of a wakame extract in the preparation of alpha-glucosidase inhibitors. Background technique [0002] Diabetes is a common metabolic disease group characterized by chronically elevated blood sugar levels. Long-term elevated blood sugar can easily damage blood vessels and endanger the heart, brain, kidneys, eyes and other organs, seriously affecting human life safety. For this reason, people are devoting themselves to researching the medicine that suppresses blood sugar raising. At present, α-glucosidase inhibitors such as acarbose are considered to be the first choice of oral hypoglycemic drugs due to their effects of inhibiting the rate of decomposition of starch into glucose and slowing down the intestinal absorption of carbohydrates. However, new oral hypoglycemic drugs such as acarbose tablets have also been found in clinical medication, w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/03A61P3/10
CPCA61K36/03A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor 戴聪杰黄晓冬黄世英高蓉韦兰妮
Owner QUANZHOU NORMAL UNIV
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