A kind of preparation method of medical flexible gradient vessel catheter

Abstract

The invention discloses a production method of a medical flexible gradual-change vessel catheter and belongs to the technical field of medical equipment production. The production method includes: using nylon block copolymer, hydroxyethyl methylacrylate-methyl methacrylate and collagen as the raw materials; using a LiBr or LiCl aqueous solution to extract the crushed and sterilized collagen; centrifuging; performing dialysis in ultrapure water to obtain dialysate; centrifuging the obtained dialysate to remove precipitates, and concentrating to obtain a mixed collagen aqueous solution; adding acovalent cross-linking agent, sufficiently and evenly mixing, and injecting into a sterile die to obtain a semi-finished flexible gradual-change vessel catheter; placing into a sterile plate, freezing, performing overnight freeze drying in a freeze vacuum drying machine under zero degree, and taking out the catheter obtained after the freeze drying from the die. The flexible gradual-change vesselcatheter produced by the method is good in bioactivity and biocompatibility, capable of achieving in-vivo natural degradation and capable of promoting the regeneration of long-distance injured peripheral nerves.

Description

technical field [0001] The invention relates to a preparation method of a catheter, in particular to a preparation method of a medical flexible gradient vascular catheter, which belongs to the technical field of medical device preparation. Background technique [0002] In the clinical treatment of many diseases, such as hemangiomas, blood loss and tumors, it is necessary to embolize the target blood vessels. In cancer treatment, especially for tumors that are difficult to reach and cannot be surgically removed, the blockage of blood supply is almost the only way . However, it is a very difficult operation to guide the microcatheter to travel through the blood vessel to reach the target tumor. To overcome this difficulty, medical personnel have adopted many different methods in the design and manufacture of the microcatheter. However, when drugs, therapeutic compositions or When other treatment items are delivered to the lesions to be treated, the microcatheters commonly use...

AI Technical Summary

Problems solved by technology

However, it is a very difficult operation to guide the microcatheter to travel through the blood vessel to reach the target tumor. To overcome this difficulty, medical personnel have adopted many different methods in the design and manufacture of the microcatheter. However, when drugs, therapeutic compositions or When other treatment items are delivered to the lesion to be treated, the microcatheters commonly used in the market are still prone to clogging, and high pressure is required to deliver the treatment to the target lesion

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