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Magnetic gel for assisting endoscopic mucosal dissection as well as preparation method and application system thereof

An application system and mucosal technology, applied in the directions of surgery, medical science, drug delivery, etc., can solve the problems of lack, lack of clear exposure, unfavorable for electrosurgical peeling, etc., and achieve the effect of reducing the difficulty of surgery and facilitating the operation.

Active Publication Date: 2018-05-08
崇好科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the mucosa of the lesion lacks the traction force in the opposite direction to the muscular layer, so that the gap between the mucous membrane and the muscular layer is not clearly exposed, which is not conducive to the stripping of the electric knife between the mucous membrane and the muscular layer.

Method used

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  • Magnetic gel for assisting endoscopic mucosal dissection as well as preparation method and application system thereof
  • Magnetic gel for assisting endoscopic mucosal dissection as well as preparation method and application system thereof

Examples

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preparation example Construction

[0030] The preparation application of this gel comprises the following steps:

[0031] Step 1, fully dissolving the sodium alginate powder treated by autoclaving with sterile deionized water to form a sodium alginate solution with a mass concentration of 1-3%;

[0032] Step 2, fully oscillate and mix the sterilized permanent magnetic material particles and the obtained sodium alginate solution according to the ratio of (1-20) g: (1) ml to prepare A liquid, and store it for later use;

[0033] Step 3, fully dissolving the calcium chloride powder processed by autoclaving and adding sterile deionized water to form a calcium chloride solution with a mass concentration of 0.1-5%, as liquid B; or, adding a mass concentration of 0.5-1% The aseptic medical dyes are added to the obtained calcium chloride solution in a ratio of 1:1 and mixed to prepare liquid B (finally a colored magnetic gel can be formed);

[0034] Step 4. When using, liquid A and liquid B are quickly mixed according...

Embodiment 1

[0044] A magnetic gel for assisting endoscopic mucosal dissection is prepared by mixing permanent magnetic material particles, 3% sodium alginate solution, 3% calcium chloride solution and 1% medical dye.

[0045] Its preparation process and application include the following steps:

[0046] Step 1, fully dissolving the sodium alginate powder treated by autoclaving with sterile deionized water to form a 3% sodium alginate solution;

[0047]Step 2, sterilize the permanent magnetic material particles and 3% sodium alginate solution according to the ratio of 3g:6ml, fully shake and mix to prepare A liquid, and save it for later use;

[0048] Step 3, the calcium chloride powder processed by autoclaving is fully dissolved in sterile deionized water to form a 3% calcium chloride solution;

[0049] Step 4, 1% sterile medical dye is added to 3% calcium chloride solution at a ratio of 1ml:1ml and mixed evenly to prepare B solution, which is stored for later use;

[0050] Step 5. When ...

Embodiment 2

[0052] A magnetic gel for assisting endoscopic mucosal dissection is prepared by mixing permanent magnetic material particles, 1% sodium alginate solution, 1% calcium chloride solution and 0.5% medical dye.

[0053] Its preparation process and application include the following steps:

[0054] Step 1, the sodium alginate powder processed by autoclaving is fully dissolved in sterile deionized water to form a 1% sodium alginate solution;

[0055] Step 2, sterilize the permanent magnetic material particles and 1% sodium alginate solution according to the ratio of 2g: 3ml, fully shake and mix to prepare A liquid, and save it for later use;

[0056] Step 3, the calcium chloride powder processed by autoclaving is fully dissolved in sterile deionized water to form a 1% calcium chloride solution;

[0057] Step 4, 0.5% sterile medical dye is added to 1% calcium chloride solution at a ratio of 2ml:2ml and mixed evenly to prepare B solution, which is stored for later use;

[0058] Step ...

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Abstract

The invention discloses magnetic gel for assisting endoscopic mucosal dissection. The magnetic gel is prepared mainly from permanent magnetic material microparticles, a sodium alginate solution and acalcium chloride solution, and medical dye can also be added; a preparation method thereof comprises the following steps: preparing the sodium alginate solution, adding the permanent magnetic materialmicroparticles, uniformly mixing to obtain a solution A, and using the calcium chloride solution or a mixed solution of the calcium chloride solution and the medical dye as a solution B; filling a double-cavity synchronous injection device with the solution A and the solution B respectively, and injecting an appropriate amount of an uniformly mixed solution into a mucosal lesion to be dissected according to the size of the lesion during using, wherein the uniformly mixed solution can form the magnetic gel in the lesion within a short time. The application system comprises the double-cavity synchronous injection device for injecting the uniformly mixed solution into the mucosal lesion to be dissected, and a detachable magnetic ring at the head end of an endoscope, wherein the uniformly mixed solution forms the magnetic gel after injection. Through magnetic attraction between the magnetic gel and the detachable magnetic ring at the head end of the endoscope, a pulling force opposite toa muscular layer is provided, so that the dissection between mucosa and muscular layer is facilitated; the invention has the advantages of convenience in operation, reduction in surgical difficulty and the like.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a magnetic gel for assisting endoscopic mucosal dissection, its preparation and its application system. Background technique [0002] Endoscopic mucosal dissection is one of the important methods for the treatment of gastrointestinal mucosal lesions (including early gastrointestinal cancer, submucosal tumors, giant flat polyps of the gastrointestinal tract, etc.). The key operation in the implementation of endoscopic mucosal dissection is to use submucosal injection to separate the mucosal layer from the muscular layer and lift up the lesion, and then gradually peel off the lesion with an electric knife. The disadvantage is that the mucosa of the lesion lacks the traction force in the opposite direction to the muscular layer, so that the gap between the mucosa and the muscular layer is not clearly exposed, which is not conducive to the stripping of the elect...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/14
CPCA61B17/32A61L31/128A61L31/14A61L31/145A61L2300/442A61L2400/06C08L5/04
Inventor 严小鹏吕毅赵广宾史爱华马锋
Owner 崇好科技有限公司
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