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Sustained release tablet for curing gastritis and preparation method thereof

A technology of slow-release tablets and gastritis, applied in the field of slow-release tablets for the treatment of gastritis and its preparation, to achieve good curative effect, reduce adverse reactions, and long half-life

Inactive Publication Date: 2018-05-08
GUANGXI WANDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to the present invention, there are no reports on the composition of open arrow, double-faced needle, mulberry, tangerine core, and licorice

Method used

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  • Sustained release tablet for curing gastritis and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation method of the sustained-release tablet for the treatment of gastritis, comprises the following steps:

[0030] S1: Weigh the components according to parts by weight: 20kg of open arrow, 10kg of double-faced needle, 10kg of mulixiang, 6kg of tangerine core, and 6kg of licorice;

[0031] S2: Add the weighed open arrow, double-sided needle, Jiulixiang, orange core, and licorice, add 10 times the amount of water to decoct and extract once, decoct for 3 hours, filter, combine the filtrate, concentrate, granulate, dry, Pulverize to get dry cream powder;

[0032] S3: Add 5 kg of hydroxypropyl methylcellulose, 0.8 kg of polyvinylpyrrolidone, 3 kg of microcrystalline cellulose, and 0.5 kg of magnesium stearate to the above dry cream powder, mix well, and press into tablets to obtain the product.

Embodiment 2

[0034] The preparation method of the sustained-release tablet for the treatment of gastritis, comprises the following steps:

[0035] S1: Weigh the components according to parts by weight: 50kg of open arrow, 30kg of double-faced needle, 20kg of mulixiang, 15kg of tangerine core, and 15kg of licorice;

[0036] S2: Add the weighed Kaijianjian, LMZ, Jiulixiang, Tangerine Pit, and Licorice, add 6 times the amount of water to decoct and extract 3 times, decoct for 1 hour each time, filter, combine the filtrate, concentrate, and granulate, Dried and crushed to obtain dry cream powder;

[0037] S3: add 10 kg of hydroxypropyl methylcellulose, 1.2 kg of polyvinylpyrrolidone, 8 kg of microcrystalline cellulose, and 0.8 kg of magnesium stearate to the above dry cream powder, mix well, and press into tablets to obtain the product.

Embodiment 3

[0039] The preparation method of the sustained-release tablet for the treatment of gastritis, comprises the following steps:

[0040] S1: Weigh the components according to parts by weight: 35kg of open arrow, 20kg of double-faced needle, 15kg of mulberry, 12kg of orange core, and 9kg of licorice;

[0041] S2: Add the weighed Kaijianjian, Liangmianzhen, Jiulixiang, Tangerine Pit, and Licorice, add 8 times the amount of water to decoct and extract twice, decoct for 2 hours each time, filter, combine the filtrate, concentrate, and granulate, Dried and crushed to obtain dry cream powder;

[0042] S3: Add 8 kg of hydroxypropyl methylcellulose, 1 kg of polyvinylpyrrolidone, 5 kg of microcrystalline cellulose, and 0.6 kg of magnesium stearate to the above dry cream powder, mix well, and press into tablets to obtain the product.

[0043] 2. Clinical application

[0044] 1. Case selection criteria

[0045] All cases were in line with the diagnostic criteria of "Endoscopic Classifica...

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Abstract

The invention discloses a sustained release tablet for curing gastritis and a preparation method thereof. Raw materials comprise the following traditional Chinese medicine components in parts by weight: 20-50 parts of tupistra chinensis bak. stem, 10-30 parts of radix zanthoxyli, 10-20 parts of folium et cacumen murrayae, 6-15 parts of semen citri reticulatae, and 6-15 parts of liquorice root. Thesustained release tablet can remarkably relieve acute or chronic gastritis symptoms like upper abdominal swelling, pain, belching, dryness of mouth, epigastric upset, generation of acid, fatigue, emaciation, and poor appetite of patients, is released slowly for a long time, has high bioavailability, and has no adverse reactions.

Description

technical field [0001] The invention belongs to the field of medicines, and relates to a slow-release tablet for treating gastritis and a preparation method thereof. Background technique [0002] Gastritis is called stomach fullness in traditional Chinese medicine, epigastric pain, acid reflux, and noisy. It is an acute and chronic inflammation of the gastric mucosa caused by a variety of different etiologies, often accompanied by epithelial injury, mucosal inflammatory response, and epithelial regeneration. Gastritis is one of the most common digestive diseases. According to the priority of clinical onset and the duration of the disease, gastritis is generally divided into acute gastritis and chronic gastritis. Acute gastric mucosal inflammation is an acute onset clinically, often manifested as epigastric discomfort, dull pain and other symptoms; chronic gastritis manifests as chronic inflammation or atrophic lesions of the gastric mucosa, which is very common clinically,...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K9/22A61P1/04
CPCA61K9/2027A61K9/2054A61K36/484A61K36/75A61K36/752A61K36/758A61K36/896A61K2236/331A61K2236/39A61K2300/00
Inventor 陈刃杨坤李家宝廖厚知
Owner GUANGXI WANDE PHARMA
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