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Medicine composition for treating acute pulpitis and application thereof

A composition and a technology for pulpitis, applied in the field of oral drug research and development, can solve problems such as poor efficacy of treatment drugs for pulpitis, and achieve the effects of strong antibacterial and anti-inflammatory effects, enhanced antibacterial and anti-inflammatory effects, and reduced toxic and side effects.

Inactive Publication Date: 2018-05-01
魏立梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] In order to overcome the technical deficiencies in the prior art that the therapeutic drugs for treating pulpitis are less effective and pathogenic bacteria are more resistant to conventional antibiotics, the present invention provides a pharmaceutical composition for treating acute pulpitis and its use , the pharmaceutical composition uses morpholinidazole, artificial bezoar and matrine as the main active ingredients, which have significant synergistic therapeutic effects in antibacterial, anti-inflammatory and analgesic aspects, and are suitable for popularization and application in clinical medicine for pulpitis

Method used

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  • Medicine composition for treating acute pulpitis and application thereof
  • Medicine composition for treating acute pulpitis and application thereof
  • Medicine composition for treating acute pulpitis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1 morpholinidazole matrine compound tablet

[0025]

[0026] Preparation process: first put morpholinidazole, artificial bezoar and cyclodextrin into a mortar, grind and mix evenly, then add carboxymethyl starch sodium, compressible starch and mix evenly, finally add matrine and mix evenly, use 5 The absolute ethanol solution of %PVP is used as a binder to granulate, dried at 40°C, granulated, added with magnesium stearate, mixed evenly, and compressed into tablets.

Embodiment 2

[0027] The preparation of embodiment 2 morpholinidazole matrine compound tablet

[0028]

[0029] Preparation process: first put morpholinidazole, artificial bezoar and cyclodextrin into a mortar, grind and mix evenly, then add carboxymethyl starch sodium, compressible starch and mix evenly, finally add matrine and mix evenly, use 5 The absolute ethanol solution of %PVP is used as a binder to granulate, dried at 40°C, granulated, added with magnesium stearate, mixed evenly, and compressed into tablets.

Embodiment 3

[0030] The preparation of embodiment 3 morpholinidazole matrine compound tablet

[0031]

[0032] Preparation process: first put morpholinidazole, artificial bezoar and β-cyclodextrin into a mortar and grind and mix evenly, then add sodium carboxymethyl starch, microcrystalline cellulose, and micropowder silica gel to mix evenly, and finally add matrine Mix well, and the powder is directly compressed into tablets to obtain the product.

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Abstract

The invention relates to a medicine composition for treating acute pulpitis and application thereof, and belongs to the field of study and development of oral medicines. The medicine composition for treating the acute pulpitis and the application aim at overcoming the technical defects of poorer effect of the pulpitis treating medicine and stronger drug resistance of pathogenic bacterium to conventional antibiotics in the prior art. The medicine composition has the advantages that by using morinidazole, calculus bovis factitius and matrine as main active components, the obvious synergistic treatment effect on bacteria resisting, inflammation diminishing and pain relieving is realized, and the medicine composition is suitable for being popularized and applied to the clinical application ofpulpitis medicines.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating acute pulpitis and its application, belonging to the field of oral medicine research and development. Background technique [0002] Pulpitis is one of the most common oral diseases. When pulpitis occurs, peripheral nociceptors and central neurons in the pulp are in a state of pain sensitization. Pain-sensitized peripheral receptors have lower stimulation thresholds and increased excitability, while central neurons also experience changes such as enlarged receptive fields. Patients show symptoms of hot and cold stimulation pain, spontaneous pain, and diffuse pain. [0003] The most important cause of pulp inflammation is infection. When the hard tissue of the tooth is damaged due to various reasons, bacteria can invade and infect the pulp. Among them, dental caries is the most common cause of tooth hard tissue loss. Other reasons include tooth defect caused by abnormal tooth development...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61P1/02A61P29/00A61P31/04A61K31/4375A61K31/5377
CPCA61K31/4375A61K31/5377A61K35/413A61K2300/00
Inventor 魏立梅赵鲁明石晓蕾
Owner 魏立梅
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