New technique for extracting artemisinin

Abstract

The invention relates to a new technique for extracting artemisinin, which includes steps of 1), feeding materials: adding dried artemisinin leafs in a three-opening flask; 2), immersion: adding mixedsolvent containing more than two of ethyl formate, ethyl acetate, acetone, 2-butanone, methylene dichloride, dichloroethane, methanol, ethanol and others, and adding saturated organic solvent solution, wherein the volume ratio of mixed solution is 1-8%, and water volume ratio of saturated organic solvent solution is 85-88%; immersing for 2-3 hours; 3), extraction: extracting the immersion solution by ultrasound method; 4), filtering: filtering the mixed solution by a filter device to remove impurities; 5), checking: performing ultrasound extraction on prepared grass residue by methanol, wherein when the artemisinin content is less than 0.12%, the extraction reaches the requirement. In a word, the new technique has the advantages of being simple in preparation technique, high in purifyingefficiency, low in preparation cost, and others.

Description

technical field [0001] The invention belongs to the field of artemisinin preparation technology, and in particular relates to a new artemisinin extraction technology. Background technique [0002] Artemisinin is a colorless needle-like crystal extracted from the leaves of the compound inflorescence plant Artemisia annua, which is the traditional Chinese medicine Artemisia annua. Its stem does not contain the drug Artemisia annua. The most effective antimalarial drugs after that, especially for cerebral malaria and anti-chloroquine malaria, have the characteristics of quick action and low toxicity, and were once called "the only effective malaria treatment drug in the world" by the World Health Organization; antimalarial effect The mechanism mainly lies in the generation of free radicals through the activation of artemisinin during the treatment of malaria. The free radicals combine with malaria protein and act on the membrane structure of Plasmodium, destroying the vesicular...

AI Technical Summary

Problems solved by technology

[0002] Artemisinin is a colorless needle-like crystal extracted from the leaves of the compound inflorescence plant Artemisia annua, which is the traditional Chinese medicine Artemisia annua. Its stem does not contain the drug Artemisia annua. The most effective antimalarial drugs after that, especially for cerebral malaria and anti-chloroquine malaria, have the characteristics of quick action and low toxicity, and were once called "the only effective malaria treatment drug in the world" by the World Health Organization; antimalarial effect The mechanism mainly lies in the generation of free radicals through the activation of artemisinin during the treatment of malaria. The free radicals combine with malaria protein and act on the membrane structure of Plasmodium, destroying the vesicular membrane, nuclear membrane and plasma membrane, and the mitochondria Swelling, inner and outer membranes fall off, thereby destroying the cell structure and function of Plasmodium; in addition, artemisinin also shows attractive prospects in the treatment of other diseases; such as anti-schistosomiasis, regulating or inhibiting the immune function of humoral, improving The conversion rate of lymphocytes, choleretic, expectorant, antitussive, antiasthmatic, etc., the cost of solvents in the current extraction process is relatively high, and the operation is relatively complicated, so it is necessary to improve the extraction process of artemisinin