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Application of trichlorine substituted II-type halogenated poly-ketone compound

A polyketide compound, chlorine substitution technology, applied in the field of microorganisms, can solve the problems of low yield and small output

Active Publication Date: 2018-04-27
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] However, due to the defect of the preparation method, the yield obtained is relatively small, and the yield is also low. At the same time, because the yield is very small (about 7 mg for each compound), only the drug-resistant Staphylococcus aureus activity has been done. In order to further obtain other antibacterial activity, the applicant conducted research on the preparation method, and finally obtained the preparation method with high biomass, and conducted research on other antibacterial activities

Method used

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  • Application of trichlorine substituted II-type halogenated poly-ketone compound
  • Application of trichlorine substituted II-type halogenated poly-ketone compound
  • Application of trichlorine substituted II-type halogenated poly-ketone compound

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Embodiment Construction

[0032] The present invention will be described in further detail below by means of specific embodiments:

[0033] 1. Activation of Streptomyces sp.FJS31-2 strain

[0034] Take out the strains preserved on the glycerol slant from the -80°C refrigerator, dig out 1 ring of spores of the strain Streptomyces sp. FJS31-2 with a sterile inoculation loop, and inoculate the 11cm-diameter basal medium plate with a cross-hatch, and let it stand at 28°C Cultivate for 3 days, pick a single colony and subculture to the third generation to scale up the culture.

[0035] 2. Fermentation and cultivation of fermentation products

[0036] Streptomyces sp.FJS31-2 strains were fermented on improved GYD solid medium, and 150mL of fermentation medium was packed in a 500mL Erlenmeyer flask, and agar powder was added to each bottle according to the mass of agar powder and 1.8% of the volume of the fermentation medium. The amount of inoculum in each bottle is the amount of activated bacteria with an ...

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Abstract

The invention discloses an application of a trichlorine substituted II-type halogenated poly-ketone compound, which has the structural formula represented as follow. The compound has anti-Gram-positive bacteria, anti-Gram-negative bacteria or anti-fungus activities. Through modification of the preparation method, more trichlorine compounds can be produced. In addition, antibacterial functions of the modified compounds are screened; the results prove that the compound has wide-spectral antibacterial activities, and has the anti-Gram-positive bacteria activity, such as methicillin-resistant Staphylococcus aureus (MRSA) and drug-resistant bacteria thereof, staphylococcus epidermidis and bacillus subtilis, and the anti-Gram-negative bacteria activity, such as escherichia coli generating extended spectrum beta-lactamases (ESBL), proteusbacillus vulgaris and bacterium burger, and anti-fungus activity, such as candida albicans.

Description

technical field [0001] The present invention relates to the technical field of microorganisms, in particular to the application of a trichloro-substituted type II halogenated polyketide compound, in particular to the application of a trichloro-substituted halogenated type II polyketide compound zunyimycin C. Background technique [0002] Natural products derived from Streptomyces often have good biological activity and drug potential, and are an important source of antibiotics. However, with the abuse of antibiotics, the emergence of many "super bacteria" has brought huge challenges to the clinical treatment of diseases such as pathogenic bacterial infections, and some super bacteria have no cure. In view of the current increasingly severe antibacterial situation, increasing the research and development of antibiotics, exploring and developing new antibiotics has become a top priority, and it is also an effective way to solve the problem of antibiotic resistance. [0003] S...

Claims

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Application Information

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IPC IPC(8): A61K31/357A61P31/04A61P31/10
CPCA61K31/357Y02A50/30
Inventor 钱声艳刘建国宋长伟王方远杨彩玲王倩
Owner ZUNYI MEDICAL UNIVERSITY
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