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Evaluation method of paracancerous collagenous tissue of early gastric cancer excision specimen

A technology for early gastric cancer and paracancerous collagen, applied in the field of pathological identification, can solve problems such as reducing the quality of life of patients, achieve the effect of reducing the probability of tumor recurrence, broad clinical application prospects, and mature technology

Active Publication Date: 2018-04-13
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, about 15% of patients with early gastric cancer still have lymph node metastasis. Lymph node metastasis of tumor cells is the main contraindication for ESD in patients with early gastric cancer, which makes clinicians more inclined to allow patients with early gastric cancer to undergo surgery when making clinical decisions Surgery, on the one hand, patients with early gastric cancer without lymph node metastasis face greater surgical risks, on the other hand, it also reduces the quality of life of patients

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  • Evaluation method of paracancerous collagenous tissue of early gastric cancer excision specimen
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  • Evaluation method of paracancerous collagenous tissue of early gastric cancer excision specimen

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Embodiment 1

[0051] Such as figure 1 Shown, a kind of paracancerous collagen tissue evaluation method of early gastric cancer resection specimen, described method comprises the following steps:

[0052] (a) Sample preparation: 3 consecutive tissue sections with a thickness of 3 μm were cut from the paracancerous part of the early gastric cancer specimen for routine wax block preparation, one for hematoxylin-eosin staining, and the other for pathological Masson staining , and the remaining one was placed in a -86°C refrigerator for refrigerated storage and used as a multiphoton imaging slice to be tested;

[0053] (b) Marking the imaging area: Observe the area in the hematoxylin-eosin-stained section and the Masson-stained section that matches the collagen adjacent to the early gastric cancer under an ordinary optical microscope, and compare it with the multiphoton imaging section to be tested in step (a). For comparison, mark the corresponding region on the multiphoton imaging slice to be...

Embodiment 2

[0057] A method for evaluating paracancerous collagen tissue of a resection specimen of early gastric cancer, the method comprising the following steps:

[0058] (a) Sample preparation: 3 consecutive tissue sections with a thickness of 8 μm were cut from the paracancerous part of the early gastric cancer specimen for routine wax block preparation, one for hematoxylin-eosin staining, and the other for pathological Masson staining , and the remaining one was placed in a -86°C refrigerator for refrigerated storage and used as a multiphoton imaging slice to be tested;

[0059] (b) Marking the imaging area: Observe the area in the hematoxylin-eosin-stained section and the Masson-stained section that matches the collagen adjacent to the early gastric cancer under an ordinary optical microscope, and compare it with the multiphoton imaging section to be tested in step (a). For comparison, mark the corresponding region on the multiphoton imaging slice to be measured to obtain the marke...

Embodiment 3

[0063] A method for evaluating paracancerous collagen tissue of a resection specimen of early gastric cancer, the method comprising the following steps:

[0064] (a) Sample preparation: 3 consecutive tissue sections with a thickness of 5 μm were cut from the paracancerous part of the early gastric cancer specimen for routine wax block preparation, one was taken for hematoxylin-eosin staining, and the other was used for pathological Masson staining , and the remaining one was placed in a -86°C refrigerator for refrigerated storage and used as a multiphoton imaging slice to be tested;

[0065] (b) Marking the imaging area: Observe the area in the hematoxylin-eosin-stained section and the Masson-stained section that matches the collagen adjacent to the early gastric cancer under an ordinary optical microscope, and compare it with the multiphoton imaging section to be tested in step (a). For comparison, mark the corresponding region on the multiphoton imaging slice to be measured ...

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Abstract

The invention provides an evaluation method of a paracancerous collagenous tissue of an early gastric cancer excision specimen, and relates to the technical field of pathology identification. The evaluation method of the paracancerous collagenous tissue of the early gastric cancer excision specimen can analyze and evaluate a morphological feature and a texture feature of a multiphoton imaging of the early gastric cancer paracancerous collagenous tissue, and timely find out the change of the early gastric cancer paracancerous collagenous change, and is good for making the clinic workers learn about if the patient has the risk of lymphatic metastasis, thereby providing reference of in-operation selection and subsequent treatment of clinic doctors, providing more individual treatment plan forpatients, and finally reaching the purpose of improving patient living quality and reducing cancer recurrent probability; the evaluation method is reasonable in design, mature in technology, simple and easy to practice, wide in clinic application prospect and good in scientific research and promotion value.

Description

technical field [0001] The invention relates to the technical field of pathological identification, in particular to a method for evaluating paracancerous collagen tissue of resection specimens of early gastric cancer. Background technique [0002] According to the definition of gastric cancer classification criteria, early gastric cancer refers to the invasion of tumor cells limited to the gastric mucosa or submucosa, regardless of whether there is lymph node metastasis. In recent years, although the overall incidence of gastric cancer has decreased worldwide, the incidence of early gastric cancer has increased year by year. At present, the treatment methods for early gastric cancer mainly include surgery, that is, total or distal gastrectomy + lymph node dissection, and endoscopic submucosal resection (ESD). With the wide application of endoscopic technology, ESD has gradually replaced surgery and has become the mainstream method for the treatment of early gastric cancer....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/30G01N21/64G01N21/63
CPCG01N1/30G01N21/63G01N21/6486
Inventor 严俊陈德鑫徐硕瑀刘张苑珠李国新许春辉蒋伟李凯陈伟生
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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