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Application of parameters in SHG/TPEF images as hepatic fibrosis staging characteristic parameters of adults or children

A technology of characteristic parameters and liver fibrosis, applied in image analysis, image data processing, image enhancement, etc., can solve the problems of distinguishing between central venous area and portal area, and cannot reflect subtle changes in the degree of fibrosis

Inactive Publication Date: 2018-04-10
PEOPLES HOSPITAL PEKING UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The fibrosis score of NASH is a semi-quantitative scoring system, which cannot reflect subtle changes in the degree of fibrosis, and does not distinguish between the central venous area and the portal area
At present, there is no specific scoring system for fibrosis in adults and children with fatty liver, and there is no combination of fibrosis features quantified by multiple SHG / TPEF techniques to evaluate the severity of NAFLD fibrosis

Method used

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  • Application of parameters in SHG/TPEF images as hepatic fibrosis staging characteristic parameters of adults or children
  • Application of parameters in SHG/TPEF images as hepatic fibrosis staging characteristic parameters of adults or children
  • Application of parameters in SHG/TPEF images as hepatic fibrosis staging characteristic parameters of adults or children

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Embodiment 1 constructs SVM model

[0066] The support vector machine method (SVM) is mainly used for classification problems, and the original data x i ,i=1,...,n are projected to high-dimensional space by nonlinear mapping Make the data linearly separable in high-dimensional space.

[0067] The specific steps are:

[0068] (1) Known training set T={(x 1 ,y 1 ),...,(x n ,y n )∈(X×Y) n}, where x i ∈X=R n ,y i ∈Y={1,-1}, i=1, . . . , n. In the present invention, x i Represents several eigenvalues ​​of the sample, y i Indicates the fibrosis category of the sample.

[0069] (2) Using Gaussian RBF kernel function and penalty parameter C>0. The goal of SVM is to construct an optimal classification function, correctly divide as many samples as possible to maximize the classification interval, construct and solve the optimal problem The constraints are get the optimal solution

[0070] (3) Choose α * Positive component less than C calculate

[007...

Embodiment 2

[0111] Example 2 The sample to be tested is the distinction of adults or children

[0112] Table 1

[0113]

[0114] Differences in early fibrosis in the portal area between adults and children: After comparison, the degree of fibrosis in the adult portal area is higher than that in children at stage 0. When stage 0 changes to stage 1C, the fibrosis of the portal area in children is significantly enhanced, and the growth rate exceeds that of adults. When stage 1C changes to stage 2, there is no obvious increase in fibrosis in the portal area in children, but the fibrosis in the portal area in adults will be significantly enhanced. It can be seen that from stage 0 to stage 2, portal fibrosis in children mainly occurs in stage 1C, while that in adults mainly occurs in stage 2, as shown in Figure 9 Characteristic parameters of fibrosis in the two portal regions shown in A and 9B.

[0115] Differences in early fibrosis in the central venous region between adults and childre...

Embodiment 3

[0117] Example 3 Fibrosis Assessment:

[0118]The morphology of tissue fibrosis is highly consistent between SHG / TPEF images and stained tissues. As shown in Figure 1, there is basically no fibrosis in S0, perisinus fibrosis in S1A and S1B, and portal vein fibrosis in S1C , portal vein fibrosis and perisinusoidal fibrosis occurred simultaneously in S2, fibrous septa appeared in S3, and cirrhosis occurred in S4. Using the fibrosis characteristic parameters quantified from SHG / TPEF images to evaluate liver fibrosis, merge S1A, S1B and S1C into S1, and select 6 characteristic parameters according to the correlation between fibrosis characteristic parameters and pathological scores. StrLength-fiber bundle length, StrWidth-fiber bundle width, StrEccentricity-fiber bundle eccentricity, StrSolidty-fiber bundle firmness, #StrPT-the number of fiber bundles in the portal area, #ShortStrPT-the number of short fiber bundles in the portal area. Using 6 parameters to establish SVM fibrosis...

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Abstract

The invention relates to the field of photo-electrochemical detection, and especially relates to an application of parameters in SHG / TPEF images as hepatic fibrosis staging characteristic parameters of adults or children. Images of nonchromosomal tissues obtained from liver puncture of adults and children are formed by means of an SHG / TPEF technology, and fibrosis characteristic parameters of a central vein area / portal area / perisinusoidal area are extracted by means of a digital image processing technology. Whether a sample is an adult or child is distinguished by means of four parameters (thenumber of crosslinking points in the portal area, the percentage of accumulative collagen in the portal area, the number of accumulative long tracts in the central vein area or the number of discretethick tracts in the central vein area). Fibrosis evaluation is carried out by means of six fibrosis characteristic parameters (the fiber tract length, the fiber tract width, the fiber tract eccentricity, the fiber tract toughness, the number of fiber tracts in the portal area and the number of short fiber tracts in the portal area), and the NASH CRN stages of adults and children can be effectively distinguished.

Description

technical field [0001] The invention relates to the field of photoelectrochemical detection, in particular to the application of parameters in SHG / TPEF images as stage characteristic parameters of adult or children's liver fibrosis. Background technique [0002] Non-alcoholic fatty liver disease (NAFLD) refers to a type of chronic liver disease with liver pathological changes similar to alcoholic fatty liver disease without a history of drinking. The incidence of NAFLD in adults worldwide is about 30%. As the disease progresses, Accompanied by the aggravation of hepatic lobular inflammation and liver fibrosis, about 25% of NAFLD patients will develop non-alcoholic steatohepatitis (NASH), and even cirrhosis and liver cancer. Children, like adults, are threatened by NAFLD. The incidence of NAFLD in healthy children worldwide is 3%-10%, and the incidence of obesity is higher. [0003] At present, liver biopsy is the gold standard for assessing the degree of fibrosis in chronic...

Claims

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Application Information

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IPC IPC(8): G06T7/00G06K9/62
CPCG06T7/0012G06T2207/30056G06T2207/20081G06T2207/10056G06F18/2411
Inventor 刘峰魏来任亚运滕霄戴其尚余维淼
Owner PEOPLES HOSPITAL PEKING UNIV
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