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Drive device and cascade control method for particle movement in terminally closed microchannel

A cascade control, micro-channel technology, applied in the field of microfluidic chips, to achieve the effect of accurate tracking control

Active Publication Date: 2020-06-16
NINGBO UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Designing the chemical conditions for particle movement through chemical methods poses a great challenge to existing technologies

Method used

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  • Drive device and cascade control method for particle movement in terminally closed microchannel
  • Drive device and cascade control method for particle movement in terminally closed microchannel
  • Drive device and cascade control method for particle movement in terminally closed microchannel

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Embodiment Construction

[0044] Such as figure 1 Shown: The topology of the control device for particle movement in a terminally closed microchannel is as follows: a micropump driving NaCl solution with colloid, a micropump driving deionized water with colloid, a mixer and main channel, and a terminally closed Branch microchannel composition.

[0045] The two micropump models are both LSP01-2A, and the flow range that the micropump can control is: 0.0002μl / min-8.6699ml / min. Both NaCl solution and deionized water contained the same particle concentration (1×10 -3 μm -3 ) polystyrene fluorescent particles with a diameter of 1.01 μm, and the concentration of NaCl solution is 2×10 3 μm / L. The mixer, the main channel and the branch microchannels are all rectangular channels. The width and height of the mixer and the main channel are 200 μm×100 μm, and the length, width and height of the branch microchannels are 400 μm×20 μm×10 μm. It can be seen that the scale of the branch microchannel is much small...

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Abstract

A control device for particle movement in a terminally closed microchannel, including two micropumps, a mixer, a main microchannel and a terminally closed branch microchannel, the main microchannel communicates with the outlet of the mixer, and the branch microchannel is closed at one end , the other end is connected with the main channel, the length of the branch microchannel is much larger than its caliber, the fluid driven by each micropump contains fluorescent particles, and the high-speed camera collects the moving and distribution images of the particles in the main microchannel and branch microchannel . The cascade control method uses the optimal control strategy of the particle movement space-time evolution model to control the particle concentration distribution of the branch microchannel with the terminal closed, and then uses the rolling tracking control strategy of the concentration adjustment model and the rolling tracking control strategy based on deep learning to control the main flow. The solution concentration profile of the channel. The invention has the advantages of being able to simulate the transmission of medicine through the main blood vessel channel, to the delivery target of the medicine, and to make the medicine accurately and controlled diffuse to the closed branch blood vessel.

Description

technical field [0001] The invention relates to a microfluidic chip with a terminal-closed microchannel and a method for controlling particle movement in the terminal-closed microchannel. Background technique [0002] In the 20th century, people achieved strategic information science and technology with the help of "information" obtained by electrons flowing in semiconductors or metals; and in the 21st century, microfluidic control is achieved through aqueous solutions with soluble biomolecules or suspended cells. Flowing on the channel or plane of the chip to study life, understand life, and even partially transform life, it will also be possible to achieve a new strategic science and technology: microfluidics. Particle movement in microchannels is one of the hotspots in microfluidics research. However, in a terminally closed microchannel, since its one-end closed geometry does not allow a net fluid flow, how to effectively transport particles into the terminally closed ge...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00B01F13/00G06F30/20
CPCB01L3/5027B01L3/50273B01L2300/0861B01L2300/0809B01L2300/02B01L2200/0652B01L2200/027G06F30/20B01F33/30
Inventor 陈将进陈特欢
Owner NINGBO UNIV
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