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Applications of eight-component swertia composition in preparation of atrophic gastritis treatment drugs

A technique for atrophic gastritis and composition, which is applied in the application field of Bawei Sweater's Cabbage composition in the preparation of medicine for treating atrophic gastritis

Active Publication Date: 2018-03-27
SHANDONG JINHE DRUG RES DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Bawei Zhangyacai Pills are mainly used for the treatment of cholecystitis and jaundice hepatitis. It has been reported in the literature that the drug can also be used for neonatal hyperbilirubinemia. There is no literature or research report on its use in gastritis, especially atrophy Treatment of gastritis

Method used

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  • Applications of eight-component swertia composition in preparation of atrophic gastritis treatment drugs
  • Applications of eight-component swertia composition in preparation of atrophic gastritis treatment drugs
  • Applications of eight-component swertia composition in preparation of atrophic gastritis treatment drugs

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0015] Experimental Example 1: Animal experiment on treating atrophic gastritis with Bawei Zhangyacai Pill

[0016] 1 Experiment purpose:

[0017] To observe the therapeutic effect of Bawei Zhangyacai Pill on MNNG-induced chronic atrophic gastritis (CAG) in rats.

[0018] 2 drugs and reagents

[0019] 2.1 Experimental animals

[0020] SPF grade Wistar rats, half male and half male, license number: SCXK (Lu) 20110002, provided by Shandong Lukang Pharmaceutical Co., Ltd.

[0021] 2.2 Experimental drugs

[0022] Test drug: Bawei Swertia Pills, specification 0.24g / pill, batch number: 20121024, provided by Jinhe Tibetan Medicine Co., Ltd. The daily dosage for adults is 2.4g, and the standard adult body weight is calculated as 60kg, so the clinical daily dosage for adults is 0.04g / kg. Prepare a 1g / ml suspension with distilled water just before use.

[0023] Positive control drug: Moluodan, Handan Moluodan Pharmaceutical Co., Ltd., batch number: 110417. The daily dosage of Mol...

experiment example 2

[0103] Experimental Example 2: Clinical Observation of Bawei Zhangyacai Pills in Treating Atrophic Gastritis

[0104] 1 Materials and methods

[0105] 1.1 Inclusion and exclusion criteria

[0106] 1.1.1 Inclusion criteria:

[0107] ①Meet the diagnostic criteria for chronic atrophic gastritis;

[0108] ② Chronic atrophic gastritis was diagnosed by gastroscopy and pathological examination within 1 month before inclusion in the trial;

[0109] ③Age between 19-70 years old, regardless of gender. ④Voluntary acceptance of the drug treatment, informed consent.

[0110] 1.1.2 Exclusion criteria:

[0111] ① Those who are under 19 years old or over 70 years old, pregnant or breastfeeding women, allergic constitution and allergic to this drug;

[0112] ② Combined with peptic ulcer, severe dysplasia or suspected malignant transformation;

[0113] ③ Patients with serious primary diseases such as heart, brain, liver, kidney and hematopoietic system.

[0114] 1.2 General information ...

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Abstract

The present invention discloses new uses of Baweizhangyacaiwan. According to the present invention, the Baweizhangyacaiwan is clinically used for cholecystitis and early icteric hepatitis; the parmacological and clinical study results show that the Baweizhangyacaiwan can be used for atrophic gastritis, can significantly improve the general symptoms of atrophic gastritis animal models, can significantly increase the gastric free mucus amount (P is less than 0.05), and can significantly improve the histopathological change in the stomach; the biochemical index detection results show that the Baweizhangyacaiwan can provide the treatment effects by reducing the lipid peroxide (MDA) formation and the NO level and increasing the interleukin-12 level; and the clinical study results show that thetotal effective rate of the Baweizhangyacaiwan in the treatment of atrophic gastritis is 87.50%, and the Baweizhangyacaiwan can significantly improve symptoms such as gastrectasia, stomachache, belching, sour regurgitation and poor appetite.

Description

technical field [0001] The invention provides a new application of the composition of Swertia eight flavors, specifically relates to the application of the composition of Swertia eight flavors in the preparation of medicines for treating atrophic gastritis, and belongs to the technical field of medicine. Background technique [0002] Bawei Swertia Pill is a classic Tibetan medicine, approved by the state, the executive standard number is WS3-BC-0241-95, and the prescription consists of Swertia, Rabbit Ear Grass, Boling Melon Seeds, Horned Fennel, Bangga, Berberis Eight medicinal materials such as skin, rock ginseng, woody incense, etc., the functions and indications are clearing away heat and reducing inflammation. It is used for cholecystitis and initial jaundice hepatitis, and its ingredients are safe and have no toxic and side effects. The eight-flavored Swertia composition currently has many different dosage forms, such as pills, powders, tablets, capsules and the like....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P1/04A61P1/14A61P1/00
CPCA61K36/285A61K36/29A61K36/42A61K36/51A61K36/66A61K36/67A61K36/714A61K36/898A61K2236/33A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 姬涛王红月李玉双杨文钰李晗
Owner SHANDONG JINHE DRUG RES DEV
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