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Stable non-aqueous system containing resveratrol and preparation method of stable non-aqueous system

A technology of resveratrol and system, applied in the field of daily chemicals, can solve the problems of discoloration, inhibition of application, instability of resveratrol, etc.

Active Publication Date: 2018-03-23
GUANGZHOU KENENG COSMETICS RES CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, resveratrol is a rather unstable substance that is easily degraded by environmental factors (such as light, water, oxygen, etc.)
In the prior art, systems containing resveratrol (for example, oil-in-water or water-in-oil formulations) will undergo oxidative degradation and severe discoloration during long-term storage, thus greatly inhibiting the efficacy of this ingredient in the whitening field. application

Method used

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  • Stable non-aqueous system containing resveratrol and preparation method of stable non-aqueous system
  • Stable non-aqueous system containing resveratrol and preparation method of stable non-aqueous system
  • Stable non-aqueous system containing resveratrol and preparation method of stable non-aqueous system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] A polyol-in-oil system containing resveratrol and ferulic acid was prepared according to the following ratios.

[0073]

[0074] The process of Preparation Example 1 is similar to that of Comparative Example 1, except that 0.5wt% ferulic acid in step 2) is added after resveratrol is fully dissolved and mixed in the polyol .

[0075] The samples of Comparative Example 1 and Example 1 were respectively packed into airtight glass bottles, one full bottle and one half full bottle respectively, and then sealed. We performed accelerated oxidation experiments on 4 samples stored at 50 °C for 5 weeks. The state of the sample is as figure 2 shown.

[0076] exist figure 2 Among them, the two bottles on the left are two samples of Comparative Example 1, and the two bottles on the right are two samples of Example 1. figure 2 It was shown that the sample of Example 1 remained substantially unchanged in color after the accelerated oxidation test, while the sample of Compar...

Embodiment 2

[0078] Five polyol-in-oil systems containing resveratrol and ferulic acid were prepared according to the following ratios.

[0079]

[0080] In Example 2, Sample A is consistent with the formulation of Comparative Example 1, without adding ferulic acid. In samples B, C, D and E, 0.05 wt%, 0.10 wt%, 0.30 wt% and 1.0 wt% of ferulic acid were added respectively. The preparation method of samples B, C, D, E is the same as that of Example 1, and the corresponding formula of each sample is shown in the table above.

[0081] Five samples A-E in Example 2 were respectively filled and sealed in glass bottles. These samples were stored at room temperature for 6 weeks. Figure 3a The samples showed no discoloration. The five samples in the figure are sample A, sample B, sample C, sample D, and sample E from left to right. Sample A shows a slight pink color, while the other several samples remain white.

[0082] Another 5 full bottles of samples A-E in Example 2 were stored at 50° ...

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Abstract

The invention belongs to the field of daily chemicals, and relates to an oil-wrapping polyhydric alcohol formula comprising resveratrol and a preparation method of. A system comprises an oil phase, apolyhydric alcohol phase, an emulsifying agent, a stabilizing agent, the resveratrol and ferulic acid. The oil-coated polyhydric alcohol formula and the preparation method have the advantages that theresveratrol is dissolved in the polyhydric alcohol phase, then the polyhydric alcohol phase is wrapped in the oil phase by emulsion, so that the possibility that the resveratrol is oxidized is greatly reduced; with addition of the ferulic acid in the system, the stability of the resveratrol can be further obviously improved, and possibility is provided for wide application of the product in the whitening field.

Description

technical field [0001] The invention belongs to the field of daily chemicals and relates to a stable non-aqueous system containing resveratrol and a preparation method thereof. Background technique [0002] The chemical name of resveratrol is (E)-3,5,4-trihydroxystilbene. Resveratrol (resveratrol) is a polyphenolic compound that was first isolated from the root of a plant resveratrol (Veratrum grandiflorum) by the Japanese in 1940. Later, people also found the presence of resveratrol in grapes, and later found that it exists in many plants, such as mulberries, pomegranates, cranberries and blueberries, and even peanuts. At first, people regarded it as a kind of phytoalexin (Phytoalexin)-every plant in nature has a self-protection weapon. Resveratrol is a kind of plant produced by grape itself to prevent mold infection during the growth process. Antitoxin. In 1963, scientists discovered that resveratrol has anti-inflammatory and anti-oxidative effects, and then it was foun...

Claims

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Application Information

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IPC IPC(8): A61K8/34A61K8/36A61K8/06A61Q19/02
CPCA61K8/06A61K8/345A61K8/347A61K8/36A61K2800/30A61Q19/02
Inventor 王秋静崔英云刘孟张伟杰张楚标
Owner GUANGZHOU KENENG COSMETICS RES CO LTD
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