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Biocompatible drainage pipe for glaucoma aqueous humor and preparation method thereof

A biocompatible, glaucoma technology, applied in ophthalmic surgery and other directions, can solve problems such as affecting the curative effect, and achieve the effects of simple manufacturing process, low cost, and easy disinfection

Inactive Publication Date: 2018-03-20
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term postoperative complications such as filtration bleb fibrosis and failure are inevitable and seriously affect the curative effect of this operation.

Method used

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  • Biocompatible drainage pipe for glaucoma aqueous humor and preparation method thereof

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Effect test

Embodiment 1

[0019] Dissolve chitosan powder in dilute acetic acid with a mass fraction of 2% to prepare a chitosan solution with a mass fraction of 3%, and let it stand for defoaming; Sugar solution to make chitosan adsorbed on the template; then take out the tubular template that has adsorbed chitosan, and put it into an alkaline coagulating solution NaOH solution with a mass fraction of 4%; take it out after solidification, and put it into chitosan again alternately Sugar solution and alkaline coagulation solution, cyclic operation 5 times; wash the chitosan tube with a certain thickness obtained by washing with distilled water for 3 hours, and dry at 60 degrees Celsius; finally remove the middle tubular template to obtain a miniature chitosan tube .

Embodiment 2

[0021] Dissolve the chitosan powder in 5% dilute acetic acid to prepare a chitosan solution with a mass fraction of 5%, and let it stand for defoaming; then put the 0.6mm micro-tubular template 23G injection needle into the chitosan solution , so that chitosan is adsorbed on the template; then the tubular template that has adsorbed chitosan is taken out, and put into the alkaline coagulation liquid KOH solution with a mass fraction of 6%; after solidification, take it out, and put it into the chitosan solution alternately and alkaline coagulation solution, and circulated for 15 times; the obtained chitosan tube coated with a certain thickness was washed with distilled water for 4 hours, and dried at 70 degrees Celsius; finally, the middle tubular template was removed to obtain a miniature chitosan tube.

Embodiment 3

[0023] Dissolve chitosan powder in dilute acetic acid with a mass fraction of 8% to prepare a chitosan solution with a mass fraction of 8%, and let it stand for defoaming; Polysan solution, so that chitosan is adsorbed on the template; then the tubular template that has adsorbed chitosan is taken out, and put into an alkaline coagulating liquid NaOH solution with a mass fraction of 8%; after solidification, take it out, and put it into the shell again alternately. Polycan solution and alkaline coagulation solution, cycled 30 times; washed with distilled water to obtain a chitosan tube coated with a certain thickness for 6 hours, and dried at 80 degrees Celsius; finally, the middle tubular template was removed to obtain miniature chitosan Tube.

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Abstract

The invention discloses a biocompatible drainage pipe for glaucoma aqueous humor and a preparation method thereof. A template-freezing method is used for preparing a chitosan micro tube which is usedas a glaucoma drainage device, so that a stable biocompatible aqueous humor drainage channel is obtained. The preparation technology is simple, and the cost is low. The obtained chitosan micro drainage tube facilitates sterilization, packaging and transportation, and is a glaucoma aqueous humor drainage product which is low in cost, portable and practicable.

Description

technical field [0001] The invention specifically relates to the technical field of ophthalmic medical implant materials, in particular to a biocompatible glaucoma aqueous humor drainage tube and a preparation method thereof. Background technique [0002] Glaucoma is the second leading cause of blindness worldwide. Glaucoma is a kind of optic nerve damage disease caused by pathological high intraocular pressure. Controlling intraocular pressure has become the main means of glaucoma treatment. Although anti-glaucoma drugs and laser technology provide the technology and possibility to control intraocular pressure, due to the particularity of the disease, a considerable number of glaucoma patients have to undergo surgery. Clinically, anti-glaucoma surgery is the ultimate treatment that can effectively control the development of the disease. This operation is to create a channel from the inside of the eye to the subconjunctival outside the eyeball wall by removing the trabecul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F9/007
CPCA61F9/00736
Inventor 林全愧韩月梅赵霞
Owner WENZHOU MEDICAL UNIV
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