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Application of circdlgap4 in the preparation of drugs for the treatment of stroke

A stroke and drug technology, which is applied in the field of medicine, can solve problems affecting the integrity of the blood-brain barrier and achieve the effects of reducing blood-brain barrier damage, reducing the size of cerebral infarction, and improving neurofunctional scores

Active Publication Date: 2019-05-31
SOUTHEAST UNIV
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Problems solved by technology

Previous research in our laboratory has shown that miR-143 can regulate the integrity of the blood-brain barrier by targeting PUMA protein, but whether miR-143 affects the integrity of the blood-brain barrier by regulating mesenchymal transition is still unknown

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  • Application of circdlgap4 in the preparation of drugs for the treatment of stroke
  • Application of circdlgap4 in the preparation of drugs for the treatment of stroke
  • Application of circdlgap4 in the preparation of drugs for the treatment of stroke

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Embodiment Construction

[0016] Below by embodiment, can understand the present invention better. However, those skilled in the art can easily understand that the content described in the embodiments is only for illustrating the present invention, and should not and will not limit the present invention described in the claims.

[0017] experimental method:

[0018] Human plasma collection:

[0019] Patients with acute ischemic stroke who were admitted to the emergency department of Jiangsu Provincial People's Hospital between January 2016 and December 2016 were recruited as research objects. All patients were diagnosed with ischemic stroke by brain magnetic resonance imaging (MRI) or brain CT computed tomography. 24 hours after onset, the degree of neurological deficit in patients was evaluated by using the National Institutes of Health Stroke Scale (NIHSS). All patients with intracranial hemorrhage or unknown diseases were excluded from the group. Blood was drawn within 16.5±2.6 hours after onset...

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Abstract

The invention discloses an application of CircDLGAP4 in preparing drugs for treating stroke. The invention finds that the CircDLGAP4 is existed with a specific binding site of miR-143, and can be usedas miR-143 sponge to play a critical effect in the morbidity process of the cerebral arterial thrombosis. The CircDLGAP4 excessively expressed in the mice brain can significantly improve the brain injury caused by a tMCAO model; neurological score is improved, the area of cerebral infarction is reduced and the blood brain barrier is lightened. The study describes the acting mechanism of CircDLGAP4 in the stroke disease for the first time, and further makes that the CircDLGAP4 is expected to be a novel biomarker and a molecular treatment target point in clinically treating acute cerebral arterial thrombosis.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of CircDLGAP4 in the preparation of medicaments for treating cerebral apoplexy. technical background [0002] Stroke (also known as cerebrovascular disease, cerebral apoplexy) is one of the main causes of death and severe long-term disability. It has the characteristics of high incidence, disability, mortality and recurrence. Acute cerebral ischemia causes a series of pathophysiological injuries, including local vascular lesions and neuronal lesions in the ischemic area. At present, there are two therapeutic strategies in drug research for the treatment of acute ischemic stroke. The first is the development and research of neuroprotective agents for the purpose of protecting nerve cell function. The principle is to block nerve cell death by drugs. The cascade reaction to protect and restore the nerve function in the ischemic area; the second is to improve bloo...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7105A61P9/10
CPCA61K31/7105
Inventor 姚红红白莹沈灵张媛韩冰杨莉
Owner SOUTHEAST UNIV
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