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Magnetic nano material capable of improving intravenous thrombolysis treating efficiency and preparation method thereof

A magnetic nanometer and intravenous thrombolysis technology, applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, wave energy or particle radiation treatment materials, etc., can solve tPA difficulties, effective combination restrictions, increase cranial Internal hemorrhage rate and other issues, to achieve the effect of short half-life, reduce dosage, and increase the rate of intracranial hemorrhage

Inactive Publication Date: 2018-03-06
赵奕平 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] To sum up, the problems existing in the prior art are: the direct use of intravenous injection of tPA makes it difficult for the tPA in the systemic circulation to penetrate into the thrombus center efficiently, and is strictly limited by the 3-hour thrombolytic treatment time window; prolonging the tPA treatment time window Increased rate of intracranial hemorrhage; effective binding to tPA limited by material

Method used

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  • Magnetic nano material capable of improving intravenous thrombolysis treating efficiency and preparation method thereof
  • Magnetic nano material capable of improving intravenous thrombolysis treating efficiency and preparation method thereof
  • Magnetic nano material capable of improving intravenous thrombolysis treating efficiency and preparation method thereof

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preparation example Construction

[0049] Such as figure 1 As shown, the preparation method of magnetic nanomaterials for improving the efficiency of intravenous thrombolytic therapy provided by the embodiments of the present invention includes the following steps:

[0050] S101: Prepare Fe by solvothermal method, microwave-assisted hydrothermal method or vacuum evaporation method 3 o 4 Microrod / Fe 3 o 4 Nano stave;

[0051] S102: Obtain magnetic nanomaterials by physical adsorption or chemical bonding.

Embodiment 1

[0054] The Fe provided by the embodiments of the present invention 3 o 4 The preparation method of microrod comprises the following steps: (solvothermal method)

[0055] (1) Stir 0.6-0.8g ferric nitrate nonahydrate, 0.3-0.5g glucose and 75mL ethylene glycol at room temperature for 45 minutes to form a uniform mixture;

[0056] (2) Transfer the mixed solution to a 100mL high-pressure synthesis reactor, and react at 220°C for 12 hours;

[0057] (3) The reactant is purified with alcohol and dried at 70°C;

[0058] (4) Calcining the dried product in an alcohol-nitrogen or pure nitrogen atmosphere at 350°C for 1 to 3 hours to obtain porous Fe with a length of 1.0 to 1.4 microns. 3 o 4 -C microrods.

[0059] (5) Fe 3 o 4 -C microrods are calcined in air at 600°C for 2 hours, and then placed in an alcohol-nitrogen atmosphere and calcined at 350°C for 30 minutes to obtain porous Fe with a length of 1.0-1.4 microns and a width of 0.4-0.7 microns 3 o 4 Microrods (such as figu...

Embodiment 2

[0061] The Fe provided by the embodiments of the present invention 3 o 4 The preparation method of nanorod comprises the following steps: (microwave-assisted hydrothermal method)

[0062] (1) Stir 20mM~4mM ferric chloride hexahydrate, 0.45mM~0.08mM sodium dihydrogen phosphate and 10mL deionized water at room temperature for 45 minutes to form a uniform mixture;

[0063] (2) Transfer the mixed solution to a 30mL microwave-assisted hydrothermal synthesis reactor, and react at 160°C for 30min;

[0064] (3) Purify the reactant with deionized water and dry it at 70°C;

[0065] (4) Calcining the dried product at 350° C. for 30 minutes under an alcohol-nitrogen atmosphere to obtain Fe with a length of 50 to 400 nanometers and a width of 30 to 70 nanometers. 3 o 4 Nanorods (such as image 3 shown).

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Abstract

The invention belongs to the technical field of magnetic nano materials, and discloses a magnetic nano material capable of improving intravenous thrombolysis treating efficiency and a preparation method thereof. The method comprises the following steps: performing surface modifying on a Fe3O4 magnetic nano rod / Fe3O4 nano rod, and covalently binding with a tissue plasminogen activator; binging themagnetic nano road and the tissue plasminogen activator molecules; and realizing targeted therapy under the guide of an outside magnet; the magnetic nano material comprises the tissue plasminogen activator and the Fe3O4 nano rod. Compared with other magnetic materials, the prepared Fe3O4 magnetic nano bar has the advantages of being nontoxic and porous in structure, and can be covalently bound with tPA after surface modification; the tPA-nano rod is capable of effectively releasing the carried tPA in the outside rotating magnetic field, thus accelerating thrombolysis.

Description

technical field [0001] The invention belongs to the technical field of magnetic nanometer materials, and in particular relates to a magnetic nanometer material and a preparation method thereof for improving the treatment efficiency of intravenous thrombolysis. Background technique [0002] Clinical studies have confirmed that intravenous application of tissue plasminogen activator (Tissueplasminogen activator, tPA) for systemic thrombolytic therapy can improve the prognosis of patients with acute ischemic stroke. Intravenous thrombolytic therapy in the acute phase is currently the only approved treatment. However, direct use of intravenous tPA makes it difficult for systemic circulating tPA to efficiently penetrate into the thrombus center, and is strictly limited by the 3-hour thrombolytic treatment time window. It is generally believed that intravenous injection of tPA within 3 hours of acute ischemic stroke is relatively safe. However, since tPA is a physiological agonis...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K47/52A61K41/00A61K38/49A61P7/02A61P9/10
CPCA61K9/0009A61K9/0019A61K38/49A61K41/00
Inventor 赵奕平朱露黄为杰吴莹
Owner 赵奕平
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