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Method for rapidly screening and certifying veterinary drug residue in milk

A fast technology for veterinary drug residues, applied in the field of analytical chemistry, to achieve long processing time, good accuracy and repeatability

Active Publication Date: 2018-02-23
梅里埃检测技术(宁波)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the deficiencies in the prior art, the present invention aims to provide a method for quickly screening and confirming veterinary drug residues in milk by using QuEChERS EMR-Lipid technology combined with LC-QTOF, so as to find problems that are difficult to find in daily detection and meet the requirements of evaluation and Regulatory Requirements for Drug Residues in Milk

Method used

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  • Method for rapidly screening and certifying veterinary drug residue in milk
  • Method for rapidly screening and certifying veterinary drug residue in milk
  • Method for rapidly screening and certifying veterinary drug residue in milk

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Experimental program
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Embodiment

[0044] 1 Experimental part

[0045] 1.1 Instruments and equipment

[0046] Agilent 1290 ultra-high performance liquid chromatography, G6530A Q-TOF quadrupole time-of-flight mass spectrometer, equipped with DualAgilent Jet Stream Electrospray Ionization (Dual AJS ESI) source (Agilent, USA); MultiReax vortex oscillator (Heidolph, Germany), 3-30KS refrigerated centrifuge (Sigma, Germany), Milli-Q ultrapure water machine (Millipore, USA), XS205Du electronic balance (Mettler-Toledo, Switzerland).

[0047] 1.2 Reagents, drugs and materials

[0048] Veterinary drug standard substance: purity ≥ 95% (Dr. Ehrenstorfer GmbH); Acetonitrile and methanol are chromatographically pure (Merck, Germany); Degreasing dispersion purification package (Agilent Bond Elut dSPE Enhanced Matrix Removal (EMR)-Lipid, product number : 5982-1010); degreasing extraction salt bag (Bond Elut EMR-Lipid Polish Pouch, anhydrous MgSO4 only, product number: 5982-0102); ceramic homogenizer (suitable for 50 mL cent...

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Abstract

The invention discloses a method for rapidly screening and certifying veterinary drug residue in milk. The method comprises the following steps: extracting a sample by 5% of formic acid acetonitrile,purifying by a QuEChERS EMR-Lipid technology, and screening and certifying by LC-QTOF. A first-level screening spectrum library of 134 drugs is built, and the methodology validation is performed to 40common veterinary drugs. The method has the good sensitivity, accuracy and repeatability. The first-level spectrum library scanning is performed to the practical sample, the discovered veterinary drug residue is further certified through the second-level mass spectrum analysis, and finally a standard substance is used for verification. The method is capable of discovering the problems which are hardly discovered in the daily detection, and satisfying the requirements of evaluating and supervising the drug residue in the milk.

Description

technical field [0001] The invention belongs to the field of analytical chemistry, in particular to a method for quickly screening and confirming veterinary drug residues in milk. Background technique [0002] Veterinary drugs have been widely used in the dairy farming industry. The use of a certain amount of veterinary drugs can prevent and treat dairy cow diseases and reduce the losses of dairy farming enterprises. However, if illegally added, improperly used or excessively used, it will cause excessive residues of milk drugs and enter through the food chain. Human body, leading to drug resistance, allergic reaction, etc. in the human body, can induce the occurrence of serious diseases, thereby endangering the health of consumers, especially infants, the elderly, and special groups suffering from diseases, which may cause greater harm. What's more, some criminals use human antibiotics on cows, which makes the problem of veterinary drug residues in milk more complicated. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/047G01N2030/062
Inventor 蒋万枫张凤艳
Owner 梅里埃检测技术(宁波)有限公司
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