Method for preparing magnetic nanoparticles with improved quality

Abstract

The invention discloses a method for preparing magnetic nanoparticles with improved quality. The method comprises the following steps: weighing a soluble trivalent iron salt and sodium acetate to be dissolved in ethylene glycol so as to obtain yellow transparent liquid; adding trisodium citrate, a polyvinylpyrrolidone dispersing agent and an alkaline additive, and mechanically stirring at a room temperature; and adding the obtained mixed liquid into a reactor to be reacted, naturally cooling the product, washing with ethanol and water, and performing vacuum drying, thereby obtaining the magnetic nanoparticles. According to the method for preparing magnetic nanoparticles disclosed by the invention, ferroferric oxide magnetic nanoparticles are synthesized by a solvothermal method, synthesisis completed at a time under high temperature and high pressure, later crystallization treatment is not needed, the obtained powder is narrow in particle size distribution and pure in components, andanhydrous sodium acetate with excellent electrostatic stability is selected as the alkaline additive, so that agglomeration of the magnetic nanoparticles is effectively avoided. Therefore, the prepared ferroferric oxide magnetic nanoparticles are excellent in stability and have excellent monodispersity, superparamagnetism and particle size uniformity in water.

Description

technical field [0001] The invention relates to a preparation process of inorganic materials, in particular to a method for preparing magnetic nano microspheres with improved quality. Background technique [0002] As a soft magnetic material, magnetic nanomaterials are widely used in magnetic media storage, magnetic resonance imaging, catalysts and other fields. Iron tetroxide has attracted much attention due to its good magnetic properties, biocompatibility and low toxicity. At present, The research on ferroferric oxide has been extended to the field of biomedicine, especially the research on targeted drug delivery. Using an external magnetic field can enrich the magnetically targeted drug carrier containing nanometer ferric oxide in the lesion in the body, reducing the Small normal tissue drug contact, reduce toxic and side effects, can effectively reduce the amount of drugs, improve the efficacy of drugs. [0003] At present, the preparation methods of ferroferric oxide ...

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is that the preparation method of the existing ferroferric oxide magnetic nano microspheres has poor dispersion, non-uniform particle size, difficult size control, and easy generation of impurity phases, making the product impure. The purpose is to provide magnetic materials with improved quality. The preparation method of nano-microspheres, using the solvothermal method to synthesize ferroferric oxide magnetic nano-microspheres, which is completed at one time under high temperature and high pressure, without the need for later crystallization treatment, the obtained powder has a narrow particle size distribution, pure components, and good electrostatic stability. Anhydrous sodium acetate is used as an alkaline additive, thereby effectively avoiding the agglomeration of magnetic nanoparticles, so that the prepared ferroferric oxide magnetic nanospheres have good stability, and have good monodispersity, superparamagnetism and Particle size uniformity