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A kind of fat-soluble drug submicrocapsule glucose injection and preparation method thereof

A technology for glucose injection and fat-soluble drug, applied in the field of fat-soluble drug submicrocapsule glucose injection and preparation thereof, can solve the problems of poor stability, low drug loading, low submicrocapsule safety and the like, and achieves easy control, High drug loading and good blood compatibility

Active Publication Date: 2020-01-03
CHONGQING UNIV OF TECH
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0004] In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a fat-soluble drug submicrocapsule glucose injection and a preparation method thereof, which solves the problem of low safety, poor stability, and drug loading capacity of the existing fat-soluble drug submicrocapsules. low technical issues

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  • A kind of fat-soluble drug submicrocapsule glucose injection and preparation method thereof
  • A kind of fat-soluble drug submicrocapsule glucose injection and preparation method thereof
  • A kind of fat-soluble drug submicrocapsule glucose injection and preparation method thereof

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Embodiment Construction

[0031] Below in conjunction with specific embodiment (only with zedoary oil-soluble medicine) and accompanying drawing, the embodiment of the present invention is described in further detail, and implementation case is carried out under the premise of technology of the present invention, now provides detailed embodiment and concrete To illustrate the inventiveness of the present invention, but the scope of protection of the present invention is not limited to the following examples.

[0032] Apparatus used in the embodiment of the present invention: shearing emulsifier (JRJ300-S, Shanghai Suoying Instrument Equipment Co., Ltd.); mechanical electric agitator (OS20-PRO, Beijing Kebo Saier Technology Co., Ltd.); electronic analytical balance ( METTLERAE240, Mettler-Toledo Instruments (Shanghai) Co., Ltd.); desktop high-speed microcentrifuge (D3024R, Beijing Kebo Saier Technology Co., Ltd.); upright biological microscope (SWG-W2705, Shenzhen Weiguan Optical Instrument) ; Raw mater...

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Abstract

The invention discloses a fat-soluble drug submicron capsule glucose injection and a preparation method thereof. The invention is characterized in that the capsule material comprises the following components in parts by weight: 15-45 parts of sodium alginate, 2.5-9 parts of poloxamer 188, 1.5-5 parts of silk fibroin, 0.5-3 parts of polyvinyl alcohol and 0.2-3 parts of polyethylene glycol. The preparation method comprises the following steps of: sequentially adding the poloxamer, a silk fibroin aqueous solution, a polyvinyl alcohol aqueous solution, the polyethylene glycol and glucose into a sodium alginate aqueous solution at intervals under stirring, and finally dropwise adding a corresponding fat-soluble drug; adopting an ultrasonic and shearing treatment mode; and finally, carrying outfiltration with a 450nm membrane and damp-heat sterilization to obtain the submicron capsule glucose injection. The preparation process of the submicron capsule glucose injection provided by the invention is simple and economic, the particle size of submicron capsules is controllable and uniform, and the biological safety is high.

Description

technical field [0001] The invention belongs to the medical technical field of fat-soluble drug preparations, and in particular relates to a fat-soluble drug submicrocapsule glucose injection and a preparation method thereof. Background technique [0002] Fat-soluble drugs have significant pharmacological activity, and the active ingredients are prone to oxidative deterioration to affect drug properties, and their solubility in the human body environment is low, making it difficult to reach the effective concentration of the drug. Therefore, solubilizers are commonly used clinically to improve the stability and solubility of fat-soluble drugs, and at the same time achieve targeting, improve the bioavailability of drugs, and reduce toxic and side effects. [0003] When the bilayer membrane liposome is used as a water-soluble drug delivery system, there is still a problem of thermodynamic instability, but when it is applied to a fat-soluble drug, it is a single-layer membrane,...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K47/36A61K47/10A61K47/42A61K47/32A61K47/26
CPCA61K9/0019A61K9/1075A61K47/10A61K47/26A61K47/32A61K47/36A61K47/42
Inventor 王富平杨金兰陈忠敏庞亚妮龙海霞
Owner CHONGQING UNIV OF TECH
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