Three-phase tissue engineering scaffold

Abstract

The invention discloses a three-phase tissue engineering scaffold, which comprises a bone scaffold, a cartilage scaffold and a tendon scaffold, wherein a bone fixing wrapping page part is arranged atone end of the bone scaffold; bone page sheets are arranged at the other end of the bone scaffold in a tangent mode; bone differentiation cell sheets are arranged between the various bone page sheets;a cartilage fixing wrapping page part is arranged at one end of the cartilage scaffold; cartilage page sheets are arranged at the other end of the cartilage scaffold in a tangent mode; cartilage differentiation cell sheets are arranged between the various cartilage page sheets; a tendon fixing wrapping page part is arranged at one end of the tendon scaffold; tendon page sheets are arranged at theother end of the tendon scaffold in a tangent mode; tendon differentiation cell sheets are arranged between the various tendon page sheets; the bone page sheet at the lowest part of the bone scaffoldis connected to the cartilage page sheet at the topmost side of the cartilage scaffold; and the cartilage page sheet at the lowest part of the cartilage scaffold is connected to the tendon page sheetat the topmost side of the tendon scaffold. The tissue engineering scaffold has the advantages of being simple to prepare, convenient to uses and capable of shortening a cell removal time and improving repair quality.

Description

technical field [0001] The invention mainly relates to the defect repair technology of the joint of bone and tendon, in particular to a three-phase tissue engineering support. Background technique [0002] Bone tendon junction injury (such as patella-patella tendon injury) is a common motor system disease, its incidence is increasing year by year, and its treatment has brought a heavy economic burden to society and families. A typical bone-tendon junction consists of four layers: bone, mineralized fibrocartilage, unmineralized fibrocartilage, and tendon. Different from the repair after injury between the same tissue (such as bone-bone, tendon-tendon), the repair of bone and tendon injury occurs between two tissues with completely different structures, bone and tendon, and the bone and tendon injury is often accompanied by a fibrocartilage layer The damage of bone and tendon injury, the poor blood supply and weak regeneration ability of this part make the repair of bone and ...

AI Technical Summary

Problems solved by technology

[0003] The traditional method of treating bone-tendon junction injuries often uses various surgical suture techniques to directly fix the tendon or ligament to the bone. The bone-tendon junction is filled with fibrous scar tissue in the early stage, and the reconstruction of its characteristic fibrocartilage layer is incomplete. The regeneration of the gradient structure, so it cannot effectively disperse the stress and prevent the avulsion of the bone-tendon junction, and the reconstructed bone-tendon structure is prone to rupture again after returning to sports

In recent years, with the improvement of surgical methods and the development of postoperative rehabilitation measures, great progress has been made in the healing of bone-tendon junctions, but the injured bone-tendon junctions still cannot fully restore to the normal tissue gradient structure, and their healing The effect is unsatisfactory

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