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A Double Bionic Bone-Tendon Interface Book Holder

A bone tendon and interface technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve problems such as difficult to achieve fast and high-quality healing, and patients cannot resume sports as soon as possible, achieve excellent mechanical properties of traction, accelerate healing Cellular processes, avoiding lost effects

Active Publication Date: 2022-03-29
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is difficult for these multi-phase scaffolds to simulate the dual bionics of the bone-tendon interface morphology and mechanical properties of the organism at the same time, making it difficult for patients to resume sports as soon as possible, and it is difficult to achieve rapid and high-quality healing.

Method used

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  • A Double Bionic Bone-Tendon Interface Book Holder

Examples

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Comparison scheme
Effect test

Embodiment 1

[0019] refer to figure 1 , a double bionic bone tendon interface book support, the specific steps are as follows:

[0020] Step 1: Acquisition of normal bone-tendon interface tissue samples

[0021] Obtain the bone-tendon interface tissue from the animal corpse, and use a cryostat to correct and cut it into a rectangular parallelepiped;

[0022] Step 2. Double Bionic Bone-Tendon Interface Book Holder

[0023] (1) Decalcification of bone-tendon interface tissue: Place normal bone-tendon interface tissue in a jar, completely soak the sample in 10% EDTA decalcification solution, keep at 4°C, take out the sample every week, and replace with a new decalcification solution until the decalcification is completed . Use physical detection methods to determine whether the decalcification is complete. When the appearance of the bone area in the bone-tendon interface tissue tends to be transparent and easy to bend, the needle of a 1mL syringe can be easily inserted into the sample, ind...

Embodiment 2

[0028] A double bionic bone-tendon interface leaf bracket of the present application and the bracket of the prior art were used for the same degree of bone-tendon interface injury respectively, and it was found that the bracket of the application was better than the bracket of the prior art. Fast and excellent healing.

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Abstract

The invention belongs to the technical field of repairing bone-tendon interface damage, and in particular relates to a double bionic bone-tendon interface page holder. The specific steps are as follows: step 1, normal bone-tendon interface tissue sample acquisition; step 2, double bionic bone-tendon interface book-leaf scaffold: (1) decalcification of bone-tendon interface tissue; (2) "book page" multi-layer tissue sheet technology to prepare the scaffold; (3) Decellularization of bone-tendon interface scaffolds. This dual biomimetic scaffold can not only retain the tissue structure and matrix components, but also avoid the loss of extracellular matrix components to a certain extent, especially the loss of bioactive components; it can also ensure that the decellularized scaffold has excellent tensile mechanical properties, realizing Bone and tendon anchor quickly and securely. It can effectively accelerate the decellularization process of tissues, reduce the decellularization time, and preserve the morphology and matrix components of tissues well.

Description

technical field [0001] The invention belongs to the technical field of repairing bone-tendon interface damage, and in particular relates to a double bionic bone-tendon interface page holder. Background technique [0002] With the vigorous development of national sports and fitness activities, the national physical fitness and health awareness have been steadily improved, but it is inevitable that the incidence of various sports injuries has also increased. Among them, bone-tendon interface injuries (such as cruciate ligament injuries, rotator cuff injuries) are the most common type of sports injuries. According to statistics, in the United States alone, about 250,000 rotator cuff injuries and 100,000 anterior cruciate ligament injuries require surgical treatment each year. Although my country currently lacks relevant epidemiological data, compared with the data in the United States, bone-tendon interface injury has become an urgent challenge in the field of sports medicine ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/36A61L27/50A61F2/46
CPCA61L27/3662A61L27/3691A61L27/3687A61L27/50A61F2/4644A61L2430/40A61L2430/10A61L2300/412
Inventor 陈灿吕红斌陈洋
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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