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Application of microencapsulated astaxanthin to preparation of product for preventing and treating gout

A technology of astaxanthin and microencapsulation, which is applied in microcapsules, nanocapsules, capsule delivery, etc.

Inactive Publication Date: 2018-02-06
INNOBIO CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing research information is difficult to support the growth of astaxanthin into a commercial drug / health product for anti-gout. Therefore, more practical and effective research results and technical solutions are needed in this field to ensure the commercial application of astaxanthin

Method used

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  • Application of microencapsulated astaxanthin to preparation of product for preventing and treating gout
  • Application of microencapsulated astaxanthin to preparation of product for preventing and treating gout
  • Application of microencapsulated astaxanthin to preparation of product for preventing and treating gout

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: Preparation of astaxanthin 1% microcapsule powder

[0031] Add water to 75kg of modified starch to form a solution with a solid content of 40%, add 3kg of sodium ascorbate and stir to dissolve. Take 11.4kg of astaxanthin oleoresin with a content of 10.5%, add 1.5kg of mixed tocopherols, and stir evenly. Add the astaxanthin oleoresin into the water phase of the wall material under the stirring condition, stir evenly, homogenize twice under high pressure under 50 MPa pressure, and spray dry to obtain astaxanthin 1% CWS powder.

Embodiment 2

[0032] Example 2 Preparation of astaxanthin 2% microcapsule powder

[0033] Add 66kg of modified starch and water to form a solution with a solid content of 40%, add 4kg of sodium ascorbate, and stir to dissolve 1.5kg of ascorbic acid. Take 22.5kg of astaxanthin oleoresin with a content of 10.6%, add astaxanthin oleoresin into the water phase of the wall material under stirring conditions and stir evenly, homogenize under high pressure for 2 times under 55MPa pressure, and spray dry to obtain astaxanthin 2% CWS powder .

Embodiment 3

[0035] 48 rats of the present invention were adapted to 7 days in the animal room environment before the test, and were randomly divided into 6 groups, 8 of the blank control group (1 group), 8 of the GA model group (2 groups), and 8 of the colchicine group (3 groups). group) 8 rats, high-dose group (group 4) 8 rats, middle-dose group (group 5) 8 rats, low-dose group (group 6) 8 rats. Rats in each group were administered by intragastric administration for 8 days continuously, and the administration volume was as follows: 1ml / 100g, and the model was established 1h after the last administration. The rats in the colchicine group were given 1.5 mg / kg colchicine solution by intragastric administration, and the targeted drug 1 groups were given 144 mg / kg, 72 mg / kg, and 36 mg / kg by intragastric administration, respectively. Solution, continued to administer for 3 days after modeling. Rats were injected with 50 μl of 5% sodium urate solution into the tibiotarsal joint cavity of the m...

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PUM

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Abstract

The invention discloses application of microencapsulated astaxanthin to preparation of a product for preventing and treating gout. Under the condition of limited administration way and administrationdosage, the microencapsulated astaxanthin is applied to clinical gout patients, is prepared from natural active ingredients with small side effects and remarkable curative effects, and brings good news to gout patients. The same standard effect cannot be achieved when the administration dosage is higher or lower than the described administration amount.

Description

technical field [0001] The invention relates to the new discovery and application of astaxanthin in the field of medical care. Background technique [0002] Gout is a crystal-associated arthropathy caused by the deposition of monosodium urate (MSU), which is directly related to hyperuricemia caused by purine metabolic disorders and / or decreased uric acid excretion, especially acute characteristic arthritis and Chronic tophi diseases mainly include acute onset arthritis, tophi formation, tophi chronic arthritis, urate nephropathy and uric acid urolithiasis. In severe cases, joint disability and renal insufficiency may occur. Gout is often accompanied by abdominal obesity, hyperlipidemia, hypertension, type 2 diabetes and cardiovascular disease. Patients in the acute attack stage of gout suffer from unbearable pain, and in severe cases, the joints deform, which brings serious physical and mental harm to the patient. However, there is currently no particularly effective drug ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61K9/51A61P19/06A61P19/02
CPCA61K31/122A61K9/5123A61K9/5161
Inventor 张琳洪永德薛凌云李倩陈剑彬吴文忠
Owner INNOBIO CORP LTD
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