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Method for improving safety of compound herba sambuci chinensis injection solution

An injection, safety technology, applied in the field of medicine, to achieve high safety, reduce the probability and risk of adverse reactions, and good safety effect

Inactive Publication Date: 2018-02-06
CHENGDU SHENGSHI GUANGHUA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the compound Luying injection produced in China also adds carbomer as a cosolvent, facing the same problem

Method used

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  • Method for improving safety of compound herba sambuci chinensis injection solution
  • Method for improving safety of compound herba sambuci chinensis injection solution
  • Method for improving safety of compound herba sambuci chinensis injection solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021]

[0022] Preparation method: Add water to decoct Luying and ghost hair needle twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the containing The amount of ethanol is 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and concentrate the filtrate under reduced pressure When the relative density is about 1.15 (80°C), the liquid medicine will be used for later use; add water and decoct twice for 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (80°C). Let it cool, add ethanol to make the ethanol content 65%, let stand overnight, filter, concentrate the filtrate under reduced pressure to a relative density of...

Embodiment 2

[0024]

[0025] Preparation method: Add water to decoct Luying and ghost hair needle twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the containing The amount of ethanol is 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and concentrate the filtrate under reduced pressure When the relative density is about 1.15 (80°C), the liquid medicine will be used for later use; add water and decoct twice for 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (80°C). Let it cool, add ethanol to make the ethanol content 65%, let stand overnight, filter, concentrate the filtrate under reduced pressure to a relative density of...

Embodiment 3

[0027]

[0028] Preparation method: Add water to decoct Luying and ghost hair needle twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the containing The amount of ethanol is 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and concentrate the filtrate under reduced pressure When the relative density is about 1.15 (80°C), the liquid medicine will be used for later use; add water and decoct twice for 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (80°C). Let it cool, add ethanol to make the ethanol content 65%, let stand overnight, filter, concentrate the filtrate under reduced pressure to a relative density of...

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PUM

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Abstract

The invention discloses a method for improving the safety of compound Luying injection. According to the method, the medicinal composition for injection is mainly prepared from the extract of Lu Ying, the extract of the hairy needles, the extract of the seeds of the iris and the hydrogenated castor oil. The method of the present invention adopts the co-solvent with better safety and more obvious solubilizing effect to replace the co-solvent carbomer that has potential safety hazards and affects product quality in the compound Luying injection, and the safety of hydrogenated castor oil is higher than that of carbomer. The dosage is lower, reducing the probability and risk of adverse drug reactions, and improving the safety of clinical medication.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method for improving the safety of compound Luying injection. Background technique [0002] The standard of compound Luying injection is recorded in the drug standard issued by the Ministry of Health (preparation of traditional Chinese medicine). It has the effects of promoting blood circulation and promoting menstrual flow, dispelling blood stasis and relieving pain. It is clinically used to treat dysmenorrhea, amenorrhea, injury from tumbling, rheumatic arthralgia, etc. [0003] Compound Luying Injection has been widely used clinically in my country for many years, and its clinical efficacy has been well received by both doctors and patients. However, in recent years, reports of adverse reactions in the clinical application of traditional Chinese medicine injections have become more and more serious, which has affected the development of traditional Chinese med...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/19A61K47/44A61K47/32A61K36/88A61P15/00A61P29/00A61P19/04
CPCA61K9/08A61K9/0019A61K9/19A61K36/07A61K36/35A61K36/88A61K47/32A61K47/44A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor 张蛟
Owner CHENGDU SHENGSHI GUANGHUA BIOTECH CO LTD
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