Pharmaceutical for treating reflux esophagitis and preparation method thereof

A technology for reflux esophagitis and drugs, applied in the direction of drug combination, medical raw materials derived from arthropods, digestive system, etc., can solve the problem that the effect cannot be optimal, and achieve the promotion of esophageal cell tissue regeneration, good therapeutic effect, Accelerate the effect of shedding

Inactive Publication Date: 2018-02-02
KUNMING SINOWAY NATURAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because there are many active ingredients in Periplaneta americana, the effect of ordinary extraction methods on specific diseases cannot be optimal. Therefore, special extraction of Periplaneta americana is required according to different diseases in order to achieve the best therapeutic effect on a certain disease. good

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Extract the medicine preparation method for treating reflux esophagitis from Periplaneta americana, adopt following technology to realize:

[0036] A, the dried Periplaneta americana body is crushed through a 10-mesh sieve, and the obtained Periplaneta americana coarse powder is soaked in 60% ethanol, so that the ethanol liquid level is higher than the coarse powder liquid level 5cm, airtightly preserved for 18 months, Prepare coarse powder mixed liquor;

[0037] B. Ultrasonic extraction of the coarse powder mixture obtained in step A for 3 times at a temperature of 30°C. The ultrasonic power is: 20KHz. When extracting the coarse powder mixture for the first time, increase the weight of the coarse powder to 5 times the concentration of 60%. The ethanol, the extraction time is 30min; After the second time, the ethanol of 3 times the concentration of 60% of the thick powder weight is extracted each time, and the extraction time is 2min; the combined extracts are filtered ...

Embodiment 2

[0053] Extract the medicine preparation method for treating reflux esophagitis from Periplaneta americana, adopt following technology to realize:

[0054] A, the dried Periplaneta americana body is crushed through a 40-mesh sieve, and the obtained Periplaneta americana coarse powder is soaked in 95% ethanol, so that the ethanol liquid level is higher than the coarse powder liquid level 10cm, sealed for 7 days, and prepared Obtain coarse powder mixture;

[0055] B. Ultrasonic extraction of the coarse powder mixture obtained in step A at a temperature of 50°C for 5 times, the ultrasonic power is: 30KHz, when the coarse powder mixture is extracted for the first time, increase the weight of the coarse powder to 8 times the concentration of 95% The ethanol, extraction time is 60min; Extract the ethanol of thick powder weight 6 times of concentration 95% ethanol at every turn after the second time, extraction time is 50min; Merge extract, filter to obtain Periplaneta americana ethan...

Embodiment 3

[0070] Extract the medicine preparation method for treating reflux esophagitis from Periplaneta americana, adopt following technology to realize:

[0071] A, the dried Periplaneta americana body is crushed through a 20-mesh sieve, and the obtained Periplaneta americana coarse powder is soaked in 75% ethanol, so that the ethanol liquid level is higher than the coarse powder liquid level 8cm, and it is sealed for 12 months. Prepare coarse powder mixed liquor;

[0072] B, carry out ultrasonic extraction 3 times to the coarse powder mixture obtained in step A:

[0073] The first ultrasonic extraction: temperature 30°C, ultrasonic power 20KHz, add 5 times the weight of coarse powder with 75% ethanol, and the extraction time is 30 minutes;

[0074] The second ultrasonic extraction: the temperature is 35°C, the ultrasonic power is 23KHz, and the concentration of 75% ethanol is 3 times the weight of coarse powder, and the extraction time is 20 minutes;

[0075] The third ultrasonic ...

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PUM

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Abstract

The invention relates to a pharmaceutical for treating reflux esophagitis and a preparation method thereof. The preparation method comprises the following steps: A, smashing American cockroach, soaking in ethyl alcohol to obtain mixed liquor; B, performing ultrasonic extraction to the mixed liquor in 30-50 DEG C, wherein the ultrasonic power is 20-30 KHz, to obtain ethanol extract; C, concentrating the ethanol extract to obtain American cockroach polypide ethanol concentrated liquor; D, adding 7-10 times of water to the ethanol concentrated liquor, stirring, heating, stewing and layering; E, filtering under layer water liquor obtained in the step D, and adsorbing by activated carbon; F, loading the activated-carbon-contained liquor obtained in the step E in a chromatographic column, releasing the liquor, washing the activated carbon, and discarding washing liquid; eluting by an eluent, and filtering to obtain elution filtrate; G, concentrating the elution filtrate obtained in the stepF to obtain American cockroach extract for treating the reflux esophagitis; and H, drying and smashing the American cockroach extract for treating the reflux esophagitis obtained in the step G to obtain an American cockroach extract finished product for treating the reflux esophagitis. The pharmaceutical has the remarkable treatment effect of treating the reflux esophagitis.

Description

technical field [0001] The invention relates to a medicine preparation method, in particular to a medicine preparation method for treating reflux esophagitis. Background technique [0002] From the perspective of traditional Chinese medicine, reflux esophagitis is generally divided into the following types. [0003] Liver Qi invading the stomach type: the main manifestations are pantothenic acid, retrosternal and epigastric burning discomfort, fullness and pain, epigastric pain and hypochondriac, frequent belching, difficulty swallowing, poor stool, often pain attacks due to emotional factors, thin white tongue coating , pulse string. When treating with soothing the liver and regulating the flow of vital energy. [0004] Liver-stomach stagnation-heat type: mainly manifested as burning discomfort in the retrosternal and epigastric cavity, pain, acute pain, irritability, pantothenic acid and noisy, dry and bitter mouth, red tongue with yellow coating, stringy or rapid pulse....

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P1/04
CPCA61K35/63
Inventor 郝振平徐溧
Owner KUNMING SINOWAY NATURAL PHARMA
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