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Subcutaneous embedded sustained release preparation for efficiently preventing and treating animal acariasis

A slow-release preparation and acariasis technology, which is applied to medical preparations containing active ingredients, drug combinations, drug delivery, etc., can solve the problem of inability to kill eggs, larvae, and nymphs, affecting the economic benefits of farmers, and medication methods Improper grasp of issues such as long-lasting drug effects, reduction of animal poisoning deaths and drug-resistant mites, long-acting slow-release treatment and prevention of animal acariasis

Inactive Publication Date: 2018-02-02
NORTHEAST FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the treatment is not timely, it often leads to death, which greatly affects the economic benefits of farmers.
Because the only drugs currently on the market for the treatment of fur animal acariasis——the oral preparations or injection preparations of ivermectins (including doramectin), their acaricidal mechanism is consistent, and they can only Kills adults but not eggs, nymphs, and nymphs, so one administration can only kill part of the adults, and the life cycle of scabies is longer (the life cycle of scabies includes eggs, larvae, nymphs, and adults) stage, it takes 10 to 13 days to develop from eggs to adult mites), and adults can also be re-hatched from unkilled eggs, larvae, and nymphs. In this way, it takes several consecutive medications for a certain period of time to avoid the recurrence of fur animal mite disease attack
Farmers prefer oral administration (convenient), but the dosage and timing of medication are improperly mastered and the use of this type of drug takes a long time, resulting in the current mites have developed obvious resistance to this type of drug, and even the amount of medication has been exceeded. Difficult to eradicate mites even at toxic doses

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1. Formula ingredients

[0015] 1 part of ivermectin (or doramectin), 1 part of etoxazole, 2.5 parts of silica gel 2.

[0016] 2. Preparation method

[0017] Weigh silica gel A and the two medicines according to the proportion of the formula and mix them thoroughly, then add silica gel B (curing agent), apply it into the template, and release the mold after curing

[0018] 3. How to use

[0019] The specific usage is to embed the slow-release implant in the inner groin of the animal or in the loose subcutaneous fat tissue of the neck. It is recommended to use sterilized tweezers to pick up the drug particles and put them into the implant needle. The number of implants is set according to the weight of the animal, the severity of symptoms and the species of the animal, generally between 2-8. For example, foxes can be implanted with 2-4 grains for prevention and 3-8 grains for treatment.

Embodiment 2

[0021] 1. Formula ingredients

[0022] 1 part of ivermectin (or doramectin), 1 part of etoxazole, 0.1 part of binder (xanthan gum + ethyl cellulose = 1:1), 0.1 part of magnesium stearate

[0023] 2. Preparation method

[0024] Each component is weighed according to the formula ratio, and after mixing, it is made into implanted granules through a granulator. Granules can also be prepared by wet granulation.

[0025] 3. How to use

[0026] The specific usage is to embed the slow-release implant in the inner groin of the animal or in the loose subcutaneous fat tissue of the neck. It is recommended to use sterilized tweezers to pick up the drug particles and put them into the implant needle. The number of implants is set according to the weight of the animal, the severity of symptoms and the species of the animal, generally between 1 and 4. For example, 1-4 seeds can be implanted in foxes for prevention, and 2-5 seeds can be implanted for treatment.

Embodiment 3

[0028] 1. Formula ingredients

[0029] 1 part of ivermectin (or doramectin), 1 part of etoxazole, 0.1 part of binder (PVP+ethylcellulose=1:1), 0.1 part of magnesium stearate

[0030] 2. Preparation method

[0031] Ivermectin (or doramectin) and etoxazole were respectively made into sustained-release granules, according to the preparation method of implementation 2

[0032] 3. How to use

[0033] The method of use is the same as in Implementation 2, and the number and proportion of implantation are determined according to the stage and degree of infection of mite and the size of the animal when used.

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Abstract

The invention relates to a subcutaneous embedded sustained release preparation for efficiently preventing and treating animal acariasis. The main content includes steps of mixing drug ivermectin (Doramectin) for killing adult acarid only with drug etoxazole capable of killing acarid ova, larva or nymph or stopping their development through a proper ratio; or respectively preparing to be an animalsubcutaneous embedded sustained release preparation; embedding the preparation in an animal subcutaneous fat tissue, and keeping it to sustainably release in the animal body so that the preparation can kill the acarid in every stage in the living course and stop its development, and overcome the shortcomings of repeatedly occurred acariasis of fur-bearing animal for the ivermectin drug only can skill adult acarid but acarid ova, larva or nymph; besides, the preparation can treat and prevent the animal acariasis after long-effect sustained release, reduce the drug frequency, save labor force and reduce the risk of animal death by poison for a breeder adopts wrong drug and faster formation of acarid with drug resistance; the preparation is economic and practicable, long in drug effect lasting time, and more radical in killing acarid.

Description

technical field [0001] The invention belongs to the technical field of prevention and control of ectoparasites of fur and economic animals, and in particular relates to the development and manufacture of a subcutaneous embedded slow-release preparation for effectively preventing and controlling animal acariasis. Background technique [0002] Fur economic animal acariasis is a contagious ectoparasitic disease caused by mites belonging to Sarcoptesidae and Pruritidae that parasitize in the skin of fur animals. It can lead to hair loss, loss of appetite or no food, weight loss, anemia, and decreased immunity of affected animals, which seriously affects the fur quality, growth and reproduction of fur animals. If the treatment is not timely, it often leads to death, which greatly affects the economic benefits of farmers. Because the only drugs currently on the market for the treatment of fur animal acariasis——the oral preparations or injection preparations of ivermectins (includ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/421A61K9/16A61P33/14
CPCA61K31/7048A61K9/0024A61K9/1611A61K9/1652A61K31/421A61K2300/00
Inventor 刘玉堂
Owner NORTHEAST FORESTRY UNIVERSITY
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