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Drug delivery system of salicylic acid, and preparation method and application thereof

A drug-carrying system and salicylic acid technology, which can be used in pharmaceutical formulations, skin care preparations, cosmetic preparations, etc., can solve the problems of high irritation and easy degradation and release of salicylic acid microemulsion, and achieve good drug release characteristics. , high encapsulation rate, low irritation effect

Inactive Publication Date: 2018-01-19
上海格兰化妆品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the deficiencies in the prior art, the first object of the present invention is to provide a drug-carrying system for salicylic acid, by adopting a composite lipid carrier to embed caprylyl salicylic acid to solve the problem of high irritation of salicylic acid microemulsion, Easy to degrade and release too fast, it has the advantages of mild and non-irritating, high stability and slow release

Method used

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  • Drug delivery system of salicylic acid, and preparation method and application thereof
  • Drug delivery system of salicylic acid, and preparation method and application thereof
  • Drug delivery system of salicylic acid, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0053] Example 1: A drug-carrying system for salicylic acid, the components and their corresponding weight percentages are shown in Table 1, and are prepared through the following steps:

[0054] Step 1, turn on the cooling water of the high-pressure homogenizer, turn on the heater of the high-pressure homogenizer to heat to 85°C, start the high-pressure homogenizer, and keep the circulation to maintain the temperature of the pipeline in the machine at 85°C;

[0055] Step 2, heating the solid lipid, liquid lipid and caprylyl salicylic acid to 85°C at a constant temperature to form an oil phase;

[0056] Step 3, heating water, surfactant, pentylene glycol and lecithin at a constant temperature to 85° C. to form an aqueous phase;

[0057] Step 4, adding the oil phase to the water phase and keeping the temperature at 85°C to obtain a mixed phase;

[0058] Step 5, put the mixed phase into a high-pressure homogenizer for pre-emulsification at a speed of 7000 rpm for 100 seconds to...

Embodiment 2-9

[0064] Embodiment 2-9: A drug-carrying system for salicylic acid. The difference from Embodiment 1 is that each component and its corresponding weight percentage are shown in Table 1.

[0065] Each component and weight percent thereof in table 1 embodiment 1-9

[0066]

[0067]

Embodiment 10-20

[0068] Examples 10-20: A drug-carrying system for salicylic acid. The difference from Example 1 is that the components and their corresponding weight percentages are shown in Table 2.

[0069] Each component and weight percent thereof in table 2 embodiment 10-20

[0070]

[0071] In order to determine the most suitable liquid lipids, solid lipids and surfactants for preparing the drug-carrying system, the inventors set several liquid lipids, solid lipids and surfactants as experimental conditional factors, and sorted out Listed in Table 3.

[0072] The condition factor level table of the drug-loading system of table 3 salicylic acid

[0073]

[0074] According to the condition factors in Table 3 and 3 different condition combinations, 9 samples of the drug-loading system of salicylic acid were obtained, and the 9 samples were arranged in Table 4.

[0075] Table 4 Orthogonal table of experimental design

[0076]

[0077] Since particle size and polydispersity index ...

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Abstract

The invention discloses a drug delivery system of salicylic acid, and a preparation method and application thereof. The drug delivery system of the salicylic acid is prepared from the following components in percentage by weight: 1 to 5 percent of capryloyl salicylic acid, 10 to 30 percent of liquid lipid, 5 to 15 percent of solid lipid, 4.5 to 10 percent of interfacial active agent, 1 to 5 percent of pentanediol, 0.2 to 2 percent of lecithin, and the balance of water. The liquid lipid and the solid lipid are mixed to be used as raw materials to embed the capryloyl salicylic acid; the drug delivery system is characterized in that oil is wrapped with fat which is wrapped with water (O / F / W), and has the characteristics of high embedding rate, high drug loading capacity, high stability, low irritability and favorable drug release characteristic; a cosmetic medicine composition prepared by utilizing the drug delivery system provided by the invention for embedding the capryloyl salicylic acid is beneficial for brightening skin, removing dark spots and freckles, whitening skin, removing wrinkles, disinfecting, diminishing inflammation, removing acnes, and inhibiting melanin regeneration.

Description

technical field [0001] The invention relates to the technical field of cosmetics, more specifically, it relates to a drug-carrying system of salicylic acid and its preparation method and application. Background technique [0002] In medical cosmetology, salicylic acid is mainly used to inhibit sebum secretion, anti-inflammatory, anti-acne and keratolytic effects, remove excessively thick stratum corneum, make skin firm, smooth fine lines, fight wrinkles and melanin, improve acne folliculitis, rosacea . Caprylyl salicylic acid is a derivative of salicylic acid. It has the same effect as salicylic acid, but because of its special fatty chain structure, it is easier to penetrate into the stratum corneum and peel off old dead corneum. [0003] The development and application of nano-carriers are increasingly widespread in the fields of medical treatment and cosmetics. The carriers in the prior art include liposomes, O / W emulsions and microemulsions. The nanocarrier system can ...

Claims

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Application Information

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IPC IPC(8): A61K8/37A61K8/92A61K8/55A61K8/34A61K8/06A61Q17/00A61Q19/00A61Q19/02A61Q19/08
Inventor 庞振宜冯彩琴潘颀钧
Owner 上海格兰化妆品有限公司
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