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Hollow mesoporous silica nanoparticle loaded with rotenone and preparation method thereof

A technology of mesoporous silica and nanoparticles, applied in botany equipment and methods, microsphere preparation, microcapsule preparation, etc., can solve problems such as short duration of action, achieve good release characteristics, good control effect, and not easy The effect of drug resistance

Pending Publication Date: 2021-10-08
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The researchers found through experiments that 7.5% rotenone EC has a high control effect on the 3rd instar larvae of Spodoptera litura, but its persistence in the environment is short

Method used

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  • Hollow mesoporous silica nanoparticle loaded with rotenone and preparation method thereof
  • Hollow mesoporous silica nanoparticle loaded with rotenone and preparation method thereof
  • Hollow mesoporous silica nanoparticle loaded with rotenone and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1: Composition and preparation method of 10.0% rotenone nanoparticles: 23.8 mg of rotenone was weighed and added to 25 mL of ethanol solution to form a rotenone solution, and then 100 mg of HMSNs was added thereto. The mixed solution was stirred in a water bath at 60° C. for 6 h to allow the HMSNs to fully adsorb rotenone. Then open and stir to let the ethanol evaporate slowly to make the HMSNs in a wet state, then wash the residual rotenone on the surface of the HMSNs with 5 mL of hot ethanol solution, and then wash away the residual ethanol with deionized water. This step is repeated 3 times, and finally the washing The clean HMSNs were vacuum freeze-dried in a freeze dryer to obtain Rot@HMSNs loaded with rotenone nanoparticles.

Embodiment 2

[0046] Example 2: Evaluation of drug efficacy in the field: The experiment was conducted at Xiaoqingcai Base, Xiaoji Town, Jiangdu District, Yangzhou City, Jiangsu Province, where the larvae of Pieris rapae larvae occurred heavily. Prepare each agent into the required concentration of liquid medicine, repeat each treatment 3 times, the area of ​​the plot is 20m 2 , randomly arranged, uniformly sprayed with a knapsack sprayer, and the application rate per mu is 50kg. There are 10 plants in each district with two plants in the east, west, south, north and middle respectively. Check the base number of insect population before spraying, and check the number of live insects 7 days after spraying. Abbot's formula was used to calculate the control effect. Add trisiloxane organosilicon cationic surfactant to 10.0% rotenone nanoparticles to prepare Pickering emulsion, dilute it 1000 times, and spray it. At the same time, clear water and 10.0% rotenone suspension concentrate were res...

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Abstract

The invention relates to a hollow mesoporous silica nanoparticle loaded with rotenone and a preparation method thereof. The nanoparticle comprises an effective component and a nano-carrier, wherein the effective component is rotenone; and the rotenone accounts for 10.0% of the total weight of the nanoparticle, with the balance being the nano-carrier. According to the preparation method disclosed by the invention, a self-template synthesis method is adopted, and on the basis of synthesizing a solid mesoporous silica nanoparticle (HMSNs), water is used as an etching agent to prepare the hollow mesoporous silica nanoparticle (HMSNs). Researches show that the particle size of the prepared HMSNs is about 250 nm, and the specific surface area of the prepared HMSNs reaches 999.4 m<2> / g; and biogenic pesticide rotenone (Rot) is loaded into pores of the HMSNs through a solvent evaporation method, and the prepared rotenone-loaded nanoparticle (Rot-coated HMSNs) is uniform in particle size, has a drug loading rate of 46.7%, has good release characteristics and shows good prevention and treatment effects on imported cabbageworm larvae.

Description

technical field [0001] The invention relates to a hollow mesoporous silica-loaded rotenone nanoparticle and a preparation method thereof, belonging to the technical field of plant protection. Background technique [0002] Hollow microspheres are nanomaterials with a special structure. Compared with materials of similar size, hollow microspheres have the characteristics of low relative density and less raw material usage. However, when there is no channel on the surface of the hollow microsphere, it is difficult to release the drug in the inner cavity, so the connectivity of the microsphere channel is very important. Hollow mesoporous silica nanoparticles (HMSNs) have the dual characteristics of mesoporous and hollow inner cavity structure, and their specific surface area is considerable, and they have good biocompatibility and stability, and are good candidates for loading pesticides. carrier. In recent years, researchers have also demonstrated that HMSNs loaded with pesti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/90A01N25/08A01P7/00A01P7/04B01J13/02
CPCA01N43/90A01N25/08B01J13/02
Inventor 孟志远范添乐陈小军王智超徐王瑾刘莉杨春梅孙成缪心忆沈殿晶林宝峰
Owner YANGZHOU UNIV
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