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Thromboelastography instrument quality control product and preparation method thereof

A quality control product, plasma technology, applied in the preparation of test samples, material inspection products, biological testing, etc., can solve the problems of high cost and complex preparation steps, and achieve low cost, simplified preparation steps, and reduced use costs. Effect

Active Publication Date: 2018-01-16
上海原科实业发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] In order to solve the problem of complex preparation steps and high cost caused by the need to extract blood coagulation factors in the preparation process of quality control products in the prior art, the object of the present invention is to provide a quality control product for thromboelastography. For this reason, the present invention will also provide a A kind of preparation method of thrombelastography instrument quality control product

Method used

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  • Thromboelastography instrument quality control product and preparation method thereof
  • Thromboelastography instrument quality control product and preparation method thereof
  • Thromboelastography instrument quality control product and preparation method thereof

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preparation example Construction

[0033] 1. Preparation of Quality Control Products

[0034] Include the following steps:

Embodiment 1

[0036] S1, collect 3000g fresh sheep whole blood, add 76g sodium citrate anticoagulant, centrifuge at 3000rpm / min for 10 minutes to obtain 1800g plasma;

[0037] S2, collect 2000g fresh sheep whole blood, add 76g sodium citrate anticoagulant, centrifuge at 3000rpm / min for 30 minutes to obtain 1200g serum;

[0038] S3, divide 1800g of plasma obtained in S1 into 3 parts, namely 600g of the first part, 400g of the second part and 800g of the third part;

[0039] S4, the first part of plasma was centrifuged at 3000rpm / min for 10 minutes to obtain 350g of factor-rich sheep plasma as the lower layer of plasma,

[0040] The measured R is 0.8min, K is 0.7min, Angle is 81.5, and MA value is 76.4mm;

[0041] S5, add 24g of barium sulfate to the second part, mix well, and centrifuge to obtain 240g of factor-deficient sheep plasma in the upper layer,

[0042] And measured R is 4.8min, Angle is 72.4, MA value is 40.3mm;

[0043] S6, freeze the third part at -80°C for 6 hours, and thaw at ...

Embodiment 2

[0049] S1, collect 3000g fresh sheep whole blood, add 76g sodium citrate anticoagulant, centrifuge at 3000rpm / min for 10 minutes to obtain 1800g plasma;

[0050] S2, collect 2000g fresh sheep whole blood, add 76g sodium citrate anticoagulant, centrifuge at 3000rpm / min for 30 minutes to obtain 1200g serum;

[0051] S3, divide 1800g of plasma obtained in S1 into 3 parts, namely 600g of the first part, 400g of the second part and 800g of the third part;

[0052] S4, the first part of plasma was centrifuged at 3000rpm / min for 10 minutes to obtain 350g of factor-rich sheep plasma as the lower layer of plasma,

[0053] The measured R is 0.8min, K is 0.7min, Angle is 81.5, and MA value is 76.4mm;

[0054] S5, add 24g of barium sulfate to the second part, mix well, and centrifuge to obtain 240g of factor-deficient sheep plasma in the upper layer,

[0055] And measured R is 4.8min, Angle is 72.4, MA value is 40.3mm;

[0056] S6, freeze the third part at -80°C for 6 hours, and thaw a...

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Abstract

The invention discloses a quality control product which comprises a quality control product 1 and a quality control product 2, wherein the quality control product 1 comprises the following components:2-6 parts by weight of factor-rich goat plasma, 2-5 parts by weight of sheep serum and 1-4 parts by weight of fibrinogen mother liquor; the quality control product 2 comprises the following components: 1 to 4 parts by weight of factor-deficient sheep plasma, 5 to 10 parts by weight of sheep serum and 0. 3 to 2 parts by weight of the fibrinogen mother liquor, the fibrinogen mother liquor is prepared by dissolving fibrinogen in the sheep serum, wherein the mass percentage of the fibrinogen is 10%; clotting factor extraction is not needed in the preparation process of the thromboelastography instrument quality control product, preparation steps are simplified, operation is easy, cost is low, results are accurate, and stability is good; test results of the thromboelastography instrument quality control product basically meet that of a quality control product produced by already listed US Haemoscope company, the thromboelastography instrument quality control product can replace the qualitycontrol product produced by the already listed US Haemoscope company, and customer use cost is reduced.

Description

technical field [0001] The invention relates to the field of quality control of blood coagulation detection items of a clinical thromboelastography instrument, in particular to a quality control product of a thromboelastography instrument and a preparation method thereof. Background technique [0002] Thromboelastography is used to monitor the coagulation state of blood samples to assist clinical evaluation of patients. Thromboelastography is widely used in the monitoring of postoperative bleeding and / or thrombosis during or after cardiac surgery, organ transplantation, tumor and radiotherapy. [0003] Thromboelastography uses a coagulation method to simulate physiological blood coagulation conditions. Some reagent is added to start the blood coagulation reaction, so that the fibrinogen in the sample is converted into cross-linked fibrin, and the sample coagulates. The motor inside the instrument drives the sample cup carrying the blood sample to rotate at a certain angle ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/28G01N1/42G01N33/86
Inventor 王连升
Owner 上海原科实业发展有限公司
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